Unprecedented Negishi coupling at C-Br in the presence of a stannyl group as a convenient approach to pyridinylstannanes and their application in liquid crystal synthesis
(Chemical Equation Presented) The 2-bromo-5(or 6)-tri-n- butylstannylpyridines, prepared from dibromopyridines and i-PrMgCl at room temperature, undergo Negishi coupling with either alkyl or arylzinc chlorides. The new alkyl- and aryl-substituted pyridylstannanes produced are shown to be suitable for further functionalization by Stille coupling. A group of new liquid crystalline materials with aromatic cores comprised of pyridine and thiophene rings were prepared utilizing these new pyridinylstannanes as key intermediates.
Getmanenko, Yulia A.,Twieg, Robert J.
p. 830 - 839
(2008/09/18)
New Synthesis of 3-Alkylpyridines
An effective method is reported for preparation of 3-alkylpyridines from piperidine and C1-C10 aliphatic alcohols at 300-500 deg C in the presence of a dehydrogenating catalyst.
Tereshko, A. B.,Tarasevich, V. A.,Kozlov, N. G.
p. 258 - 259
(2007/10/03)
DEHYDROISOMERIZATION OF N-ALKYLPIPERIDINES
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Tereshko, A. B.,Tarasevich, V. A.,Kozlov, N. G.
p. 1512
(2007/10/03)
2-Pyridylcarboxamides which inhibit arachidonic acid release
2-Pyridylcarboxamides are provided having the structure STR1 wherein n is 1 to 10; R is hydrogen, lower alkyl, alkali metal or an amine salt; and R1 is C6 -C20 alkyl, C6 -C20 alkenyl, C6 to C20 alkoxy or phenyl. These compounds are useful as inhibitors of arachidonic acid release and as such are useful as antiallergy agents.
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(2008/06/13)
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