- N,N-dialkyl-N′-chlorosulfonyl chloroformamidines in heterocyclic synthesis. VI the preparation of some fused [1,4,2,6]dithiadiazine dioxides
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N,N-Dialkyl-N′-chlorosulfonylchloroformamidines 1 were treated with 2-mercaptobenzimidazoles 2 to give [1,4,2,6]dithiadiazino[2,3-a]benzimidazole 1,1-dioxides 3. 3-Mercapto[1,2,4]triazoles 5 afforded [1,2,4]triazolo[2,3-b][1, 4,2,6]dithiadiazine 1,1-dioxides 6 and [1,2,4]triazolo[4,3-b][1,4,2,6] dithiadiazine 1,1-dioxides 7. These products are derivatives of new or very rare heterocycles. CSIRO 2008.
- Cablewski, Teresa,Francis, Craig L.,Liepa, Andris J.
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p. 332 - 341
(2008/09/19)
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- A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles
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A series of 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles was prepared for evaluation of potency and selectivity against human COX-1 and COX-2 enzymes. This lead to the discovery of L-768,277, a potent and selective COX-2 inhibitor that also demonstrated good in vivo activity.
- Roy,Leblanc,Ball,Brideau,Chan,Chauret,Cromlish,Ethier,Gauthier,Gordon,Greig,Guay,Kargman,Lau,O'Neill,Silva,Therien,Van Staden,Wong,Xu,Prasit
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- 1-Dimethylcarbamyl-3-branched alkyl-1,2,4-triazol-5-yl-(N-substituted) sulfonamides and use as insecticides
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Triazolylsulfonamides of a limited class are substantially non-phytotoxic and are useful as insecticides. For example 1-N,N-dimethylcarbamyl-3-tert.butyl-1,2,4-triazol-5-yl-N,N-dimethylsulfonamide is effective in aphid control, both by foliar application and systemically.
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