- Cyclopropane ring formation by an SmI2 mediated cyclisation of ??-halo-?±,?2-unsaturated esters
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??-Iodo- and ??-bromo-?±,?2-unsaturated esters with various substituents at the ?2- and ?3-positions readily cyclise to cyclopropane compounds in the presence of samarium diiodide and a proton source.
- David, Herveì?,Afonso, Carlos,Bonin, Martine,Doisneau, Gilles,Guillerez, Marie-George,Guibeì?, Francì§ois
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- COMPOUNDS THAT INHIBIT MCL-1 PROTEIN
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Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
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Page/Page column 1627; 1628
(2017/09/15)
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- THERAPEUTIC COMPOUNDS AND USES THEREOF
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The present invention relates to compounds formula (I): and to salts thereof, wherein R1-R4 and A have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of histone demethylases, such as KDM5. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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Paragraph 0286; 0287
(2015/03/16)
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- CALCILYTIC COMPOUNDS
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Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.
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Page/Page column 118
(2008/06/13)
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- Facile preparation of cyclopropanes from 2-iodoethyl-substituted olefins and 1,3-dihalopropanes with zinc powder
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Two efficient, simple, cheap, and environmentally benign preparations of cyclopropanes were achieved. One is the formation via 3-exo-trig manner from various electron-deficient 2-iodoethyl-substituted olefins with zinc powder in a mixture of t-butyl alcoh
- Sakuma, Daisuke,Togo, Hideo
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p. 10138 - 10145
(2007/10/03)
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- Facile and environmentally benign Zn-mediated cyclopropanation of electron-deficient 2-iodoethyl-substituted olefins via radical 3-exo-trig manner
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An efficient, simple, cheap, and environmentally benign preparation of cyclopropanes via 3-exo-trig manner from various electron-deficient 2-iodoethyl-substituted olefins with zinc powder in a mixture of f-butyl alcohol and water was achieved.
- Sakuma, Daisuke,Togo, Hideo
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p. 2501 - 2504
(2007/10/03)
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