- TYK2 INHIBITORS AND USES THEREOF
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The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
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Paragraph 00766
(2020/06/19)
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- Diversity-Oriented Synthesis of Heterocycles: Al(OTf)3-Promoted Cascade Cyclization and Ionic Hydrogenation
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An efficient and facile method has been developed for the diversity-oriented synthesis of heterocycles. Hexahydrophenoxazines, tetrahydroquinolines, indolines, hexahydrocarbazoles, and lactones were conducted via Al(OTf)3-promoted cascade cyclization and ionic hydrogenation. Furthermore, this protocol was utilized to smoothly prepare piracetam and its key intermediate as well.
- Liu, Tianqi,Jia, Wenqiang,Xi, Qiumu,Chen, Yonghui,Wang, Xiaojian,Yin, Dali
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p. 1387 - 1393
(2018/02/10)
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- A method for the preparation of pyrrolidine alkone second grade ester (by machine translation)
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The invention discloses a method for the preparation of pyrrolidine alkone second grade acid ester, the method comprising the following steps: a) the 4-amino ding Xianlu alkaliferous with halogenated acetic acid ester in the non-polar solvent in the condensation reaction, to obtain amido acetate; b) the amino-acetic acid ester in the alkaliferous non-proton polar solvents in the ring reaction lactan, pyrrolidine alkone second grade acid ester is obtained; as shown in the following synthetic route: Wherein: X chlorine, bromine or iodine; R is phenyl, benzyl or C1-C3 straight chain paraffin base. Experiment proves that: the method of the invention has the advantages of simple operation, mild reaction conditions, the low requirements for the equipment, the raw materials used are cheap and easily obtained, low production cost, easy large-scale production, and the like, in accordance with industrial preparation of pyrrolidine alkone second grade ester production requirement, has industrial application value. (by machine translation)
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Paragraph 0040; 0041; 0042
(2016/12/12)
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- Heterocyclic imino derivatives
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The invention relates to novel heterocyclic imino derivatives, several processes for their preparation and their use for controlling pests.
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- Contributions to the Knowledge of the Corrin Chromophore, VII. - Note on the Reaction of Methyl Diazoacetate with Lactams; a Model Reaction for the Cyclisation of 5,6-Dioxomonosecocorrins
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The copper-catalyzed reaction of methyl diazoacetate with the lactam 1 or the thiolactams 3 and 4 yields the O- and S-alkylated products.In the case of lactam 2 the N-alkyl compound 10 is obtained.
- Bartels, Guenter,Hinze, Ralf-Peter,Wullbrandt, Dieter
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p. 168 - 170
(2007/10/02)
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