- 3-(Benzodioxan-2-ylmethoxy)-2,6-difluorobenzamides bearing hydrophobic substituents at the 7-position of the benzodioxane nucleus potently inhibit methicillin-resistant Sa and Mtb cell division
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Lipophilic substituents at benzodioxane C (7) of 3-(benzodioxan-2-ylmethoxy)-2,6-difluorobenzamide improve the antibacterial activity against methicillin-resistant Staphylococcus aureus strains to MIC values in the range of 0.2-2.5 μg/mL, whereas hydrophi
- Straniero, Valentina,Pallavicini, Marco,Chiodini, Giuseppe,Zanotto, Carlo,Volontè, Luca,Radaelli, Antonia,Bolchi, Cristiano,Fumagalli, Laura,Sanguinetti, Maurizio,Menchinelli, Giulia,Delogu, Giovanni,Battah, Basem,De Giuli Morghen, Carlo,Valoti, Ermanno
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p. 227 - 243
(2016/05/24)
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- Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis
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Esters of 1,4-benzoxazine and 1,4-benzodioxine compounds 1 and 10, which combine thrombin inhibitory and GPIIb/IIIa antagonistic activity in one molecule are shown to inhibit endothelial cell migration and tube formation in vitro and angiogenesis in the c
- Ili?, Milo?,Ila?, Janez,Dunkel, Petra,Mátyus, Péter,Bohá?, Andrej,Liekens, Sandra,Kikelj, Danijel
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p. 160 - 170
(2013/02/23)
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- OXINDOLEDIOXANS, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO
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The present invention provides methods for preparing compounds having activity as dopamine autoreceptor agonists and partial agonists at the postsynaptic dopamine D2 receptor. These compounds are useful for treating dopaminergic disorders, such
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Page/Page column 12
(2008/06/13)
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- Melanin concentrating hormone antagonist
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A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms;Y is a bond or a spacer having a main chain of 1
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Page/Page column 85-86
(2010/11/23)
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- Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
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Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
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Page/Page column 54
(2008/06/13)
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- Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
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Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
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Page/Page column 31
(2010/11/23)
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- PYRIDO[2,3-d]PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS
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The invention describes compounds of the general formula (I), 5 a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be usefull for the treatment of diseases mediated by said tyrosine kinases.
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- Amino-substituted dihydropyrimido[4,5-D]pyrimidinone derivatives
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Compounds of formula I are described. These compounds are protein kinase inhibitors, in particular they inhibit the src family tyrosine kinases. Thus, these compounds are useful for the treatment of diseases mediated by src tyrosine kinases, including cel
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- N-BENZODIOXOLYL, N-BENZODIOXANYL AND N-BENZODIOXEPINYL ARYLCARBONXAMIDE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
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The present invention relates to a compound of the formula (I) : in which T, A, R, B Xi, Yi and n are as defined in Claim 1, and to the pharmaceutically usable derivatives, solvates and stereoisomers thereof, comprising a mixture thereof in all proportions, which can be used in the treatment of dyslipidaemia, and to pharmaceutical compositions comprising them.
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- Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
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Compounds of the general formula (I): wherein the variables are as defined in the specification are useful for the prophylaxis or treatment of serotonin-related, especially 5-HT2receptor-related, diseases in human beings or animals, particularly diseases related to the 5-HT2creceptor, especially diseases such as eating disorders, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctionions, and urinary disorders.
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