- Fe(III)-Catalyzed Aerobic Intramolecular N-N Coupling of Aliphatic Azides with Amines
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An Fe(III)-catalyzed intramolecular N-N coupling of aliphatic azidoamines that forms diverse five- and six-membered semisaturated diazoheterocycles using air as an oxidant is reported, providing an alternative to hydrazine-based methods. Mechanistic studies suggest that a N-radical induced intramolecular homolytic substitution (SH2) is involved in ring closure. The power of this N-N bond-forming method is also demonstrated by using it as the final step in a total synthesis of (-)-newbouldine.
- Zhang, Yue,Duan, Dongyu,Zhong, Ying,Guo, Xin-Ai,Guo, Jiawei,Gou, Jing,Gao, Ziwei,Yu, Binxun
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supporting information
p. 4960 - 4965
(2019/09/03)
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- Synthesis of Different Classes of Six-Membered Gold(I) NHC Complexes by the Isonitrile Route
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Different types of six-membered N-heterocyclic gold carbene complexes were prepared by using gold(I) isonitrile complexes as precursors in combination with suitably functionalized amines. The simple procedures provide an easy access to not only unsymmetrically substituted saturated carbene complexes but rarely reported types of carbene complexes such as six-membered N-heterocyclic oxo-carbene complexes, and six-membered partly unsaturated ligands can be obtained following the strategy.
- Wurm, Thomas,Mulks, Florian,B?hling, Constantin R. N.,Riedel, Dominic,Zargaran, Poorya,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.
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supporting information
p. 1070 - 1078
(2016/05/24)
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- Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine
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The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
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- 3-diphenyl substituted octahydroindolizine analgesic compounds
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Octahydroindolizine compounds of formula (I): STR1 wherein Q is --NR--, --(CH2)z --, --CH=CH--, --C C--, --OCH2 --, --SCH2 --, --SO2 --, --SO--, --CO--, or an oxygen or a sulfur atom and where R, R1 and R2 are substituents such as alkyl and x, y and z are independently the integers 0-3. Also, pharmaceutical compositions containing (I), intermediates and methods for treating pain.
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