- Fine chemicals from lignosulfonates. 2. Synthesis of veratric acid from acetovanillon
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An optimisation study based upon experimental data obtained from multivariate statistical experimental design and modelling for the haloform reaction used for synthesis of 3,4-dimethoxybenzoic acid from 3,4-dimethoxy acetophenone is reported. It is shown how the different controllable process variables influence both the yield of 3,4-dimethoxybenzoic acid and the formation of the side product 2-chloro-4,5-dimelhoxybenzoic acid. Two predictive multivariate models are derived and used to predict optimal conditions for the oxidation process. Using these models, a yield of 90% (from approximately 60%) of desired product is achieved. Moreover, the model describing the formation of the side-product can in fact also be applied to optimise a procedure for obtaining 2-chloro-4,5-dimethoxybenzoic acid in substantial quantities. One experiment showed that the side-product could be formed in a quantity of >20%.
- Bjorsvik, Hans-Rene,Norman, Kristine
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p. 341 - 346
(2013/09/08)
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