- DL-neopentyl glycine intermediate and preparation method thereof and preparation method of derivative based on intermediate
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The invention relates to the field of amino acid preparation, in particular to a DL-neopentyl glycine intermediate and a preparation method thereof and a preparation method of a derivative based on the intermediate. The preparation method of the DL-neopentyl glycine intermediate comprises an acetylation reaction, a condensation reaction, a hydrolysis reaction, an oximation reaction and a reductionreaction, and then a corresponding derivative is obtained through the acetylation reaction and resolution. According to the preparation method, the reaction time is shortened, the reaction is more thorough and the DL-neopentyl glycine can be obtained; two methods for preparing the derivative D-neopentyl glycine and the derivative L-neopentyl glycine are obtained at the same time, the prepared product is high in purity, secondary refining is not needed, the production cost is reduced, and industrial large-scale production is facilitated.
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Paragraph 0033; 0039; 0046; 0052; 0059; 0065
(2020/05/08)
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- PEPTIDES CONTAINING A NEOPENTYLGLYCINE RESIDUE
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Neopentylglycine (III, 2-amino-4,4-dimethylpentanoic acid) was synthesized in both enantiomeric forms.Using the conventional methods of peptide synthesis, L-prolyl-L-neopentylglycylglycine amide (VII), the diastereomeric cyclodipeptides cyclo(L-neopentylglycyl-L-prolyl) (IXa) and cyclo(D-neopentylglycyl-L-prolyl) (IXb) and also N-acetyl-L-neopentylglycine methylamide (X) were prepared as models for further studies on physical properties and conformation of peptides.
- Pospisek, Jan,Blaha, Karel
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p. 514 - 521
(2007/10/02)
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