NOVEL ANTI-VIRAL AGENTS BASED UPON DERIVATIVES OF THE AROMATIC HETEROCYCLE PHENANTHRIDINE
A series of substituted phenanthridine derivatives has been synthesized by converting the amines at the 3- and 8- positions of ethidium bromide into guanidine, pyrrole, urea, and various substituted ureas. The resulting derivatives exhibit unique spectral properties that change upon binding nucleic acids. The compounds have an enhanced affinity and specificity for HIV-1 Rev Response Element as compared to ethidium bromide.
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(2010/02/10)
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