MACROPHAGE IDENTIFICATION AGENT, AND IDENTIFICATION METHOD, SORTING METHOD, EVALUATION METHOD, SCREENING METHOD AND KIT USING THE MACROPHAGE IDENTIFIER AGENT
An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.
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Paragraph 0363
(2016/02/28)
Solid-phase catch, activate, and release synthesis of cyanine dyes
(equation presented) Trimethine cyanine dye was synthesized by capture and activation of a hemicyanine intermediate on sulfonyl chloride resin followed by reaction and concomitant cleavage by a heterocyclic carbon nucleophile. A small array of dyes were synthesized and characterized to demonstrate the versatility of this chemistry for a number of hemicyanines and heterocyclic nucleophiles.
Mason, Stephen J.,Balasubramanian, Shankar
p. 4261 - 4264
(2007/10/03)
CONDENSATION OF VILSMEIER COMPLEXES WITH HETEROCYCLIC COMPOUNDS. SYNTHESIS OF CARBOCYANINES
Carbocyanine dyes are formed in the reaction of the quaternary salts of heterocyclic bases containing an active methyl group with the complexes of carboxamides and phosphorus oxychloride.A series of carbocyanines were synthesized, including those containing various substituents at the meso position of the trimethine chain.