61227-25-6

[Problem] To provide a compound having a 15-PGDH inhibitory effect. [Solution] A compound represented by general formula (1) or a pharmacologically acceptable salt thereof.

Herein is reported the first total synthesis of benzyl salicylate and benzyl gentisate glucosides present in various plant species, in particular the Salix genus, such as Populus balsamifera and P. trichocarpa. The method permits the synthesis of several natural phenolic acid derivatives and their glucosides starting from salicylic or gentisic acid. The divergent approach afforded access to three different acetylated glucosides from a common synthetic intermediate. The key step in the total synthesis of naturally occurring glycosides - the selective deacetylation of the sugar moiety - was achieved in the presence of a labile benzyl ester group by employing mild deacetylation conditions. The protocol permitted synthesis of trichocarpine (4 steps, 40% overall yield), isotrichocarpine (3 steps, 51% overall yield), trichoside (6 steps, 40% overall yield), and deoxytrichocarpine (3 steps, 42% overall yield) for the first time (>95% purity). Also, the optimized mild deacetylation conditions allowed synthesis of 2-O-acetylated derivatives of all four glycosides (5-17% overall yield, 90-95% purity), which are rare plant metabolites.

The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.

A naturally occurring 1,1′-biphenanthrene, blestriarene C (1), was prepared in 13 steps and 30% overall yield. The key steps are the ester-mediated nucleophilic aromatic substitution on 2,6-ditert-butyl-4-methoxyphenyl 5-isopropoxy-2-methoxybenzoate (4) b

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4] diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

The hydroxylation process for methoxy- and hydroxy-benzoic acids (MBA, HBA) induced by γ-radiation is compared. 2-, 3-, and 4-methoxybenzoic acid as well as 3-hydroxybenzoic acid have been irradiated in N2O and aerated solutions up to 1.5 kGy. The products were analyzed by HPLC. The results for 2- and 4-HBA have been taken from literature data. The OH·-adduct distribution is generally the same for the hydroxy- as well as for the methoxy-benzoic acid isomers. With both 4-HBA and 4-MBA more than 65% C3-adducts and about 15% C4-adducts are formed, which could be proved by their reactions with K3 Fe(CN)6. Oxidation of the nonipso-adducts of 3-HBA and 3-MBA results in 84 and 87% of the corresponding phenols. Whereas in N2O-saturated solutions only part of the OH·-radicals leads to substrate decomposition, in the presence of air, the degradation of both kinds of compounds is equivalent to [OH·]. The nonipso OH·-adducts of the HBAs are converted into 68-77% hydroxylation products. With the MBAs, the hydroxylation process is ≤10%. This is attributed to different decay pathways of the peroxyl radicals, intermediates formed by O2 addition to the OH·-adducts. The hydroxyperoxycyclohexadienyl radicals of the HBAs decay mainly by HO2· elimination to the corresponding phenols, those of the MBAs decay predominantly by fragmentation of the benzene ring, yielding to nonidentified aliphatic products. The replacement of -OCH3 by -OH is practically not influenced by the presence of oxygen, it increases in the sequence 3-MBA 4-MBA 2-MBA. For 2-MBA, yields of more than 15% are obtained. Both processes, hydroxylation as well as demethoxylation, might be of importance for the recognition of radiolytical changes in foodstuff.

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

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Recently we described a new cyclisation method for the synthesis of ansa peptides by hydrogenolysis of Z-pentafluorophenyl ester and ring closure on the surface of the palladium catalyst.We applied this reaction to the synthesis of the 14-membered ansa pe