cas 612493-87-5, 1-CBZ-(S)-3-METHYLPIPERAZINE | Articles data ｜lookchem

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612493-87-5

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PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS
The present invention relates to pyrrolidine derivatives of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
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Page/Page column 28

(2010/11/08)

PROCESS FOR PRODUCING OXYCARBONYL-SUBSTITUTED PIPERAZINE DERIVATIVE
If an organic solvent with a water content of 15% or less is used when an oxycarbonyl-substituted piperazine derivative is produced from a piperazine derivative, the piperazine derivative can be oxycarbonylated.
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Page/Page column 17

(2008/06/13)

PIPERAZINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISEASES
The present invention relates to novel piperidine carbonyl piperazine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
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Page 24

(2008/06/13)

Stereoselective alkylation of chiral 2-methyl-4-protected piperazines
In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process: 1
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Page/Page column 7

(2008/06/13)

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Chemical Properties

Boiling Point: 358 °C at 760 mmHg
Flash Point:170.3 °C
Density: 1.105 g/cm³
Storage Temp.:2-8°C(protect from light)
Refractive Index: 1.5365
PKA: 8.50±0.40(Predicted)
PSA: 41.57000
LogP: 1.88360

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