- Chemoselective synthesis of quinoxalines and benzimidazoles by silica gel catalysis
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Treatment of nitroolefins and o-phenylenediamine with silica gel catalyst produced quinoxalines mainly in THF, but gave benzimidazoles efficiently in water. Such a solvent-dependent chemoselective reaction has prominent features of affording two cyclized products selectively with the same substrate, short reaction time, operational simplicity, as well as available starting materials and nontoxic catalysts. In addition, the scope and limitations were explored and a plausible reaction mechanism is proposed.
- Li, Chunmei,Zhang, Furen,Yang, Zhen,Qi, Chenze
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supporting information
p. 5430 - 5433
(2014/12/11)
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- Cu(II)-catalyzed synthesis of quinoxalines from o-phenylenediamines and nitroolefins
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An easy and efficient copper-catalyzed reaction for the synthesis of quinoxalines from o-phenylenediamines and nitroolefins is developed. This reaction could proceed well without additional base and be applied to various available substrates with a one-step synthetic procedure in moderate to good yields.
- Chen, Yongxin,Li, Kangning,Zhao, Mingming,Li, Yuanjiao,Chen, Baohua
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supporting information
p. 1627 - 1630
(2013/03/28)
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- DABCO-catalyzed oxidation of deoxybenzoins to benzils with air and one-pot synthesis of quinoxalines
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Aerobic oxidation of deoxybenzoins could be efficiently catalyzed by 1,4-diazabicyclo[2.2.2]octane (DABCO) with air as the sole oxidant to give the corresponding benzils in excellent yields. The effects of reaction conditions, such as different bases, temperature, time and solvent, on the yield of the product were investigated. Moreover, the process has been successfully extended to a one-pot synthesis of quinoxalines from benzyl ketones and aromatic 1,2-diamines. Georg Thieme Verlag Stuttgart New York.
- Qi, Chaorong,Jiang, Huanfeng,Huang, Liangbin,Chen, Zhengwang,Chen, Huoji
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experimental part
p. 387 - 396
(2011/04/15)
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