Cp*CoIII-Catalyzed C(7)–H Bond Annulation of Indolines with Alkynes
An efficient protocol for the synthesis of biologically essential pyrroloquinolinones has been developed under Cp*CoIII catalysis, which involves a cascade reaction of C(7)-H alkenylation with alkynes followed by nucleophilic addition. A wide variety of internal alkynes including enyne, diyne, and ynamide and more challenging terminal alkynes were successfully employed for the annulation in good to excellent yield with high regioselectivity.
Chemoselective synthesis of carbamates using CO2 as carbon source
Synthesis of carbamates directly from amines using CO2 as the carbon source is a straightforward and sustainable approach. Herein, we describe a highly effective and chemoselective methodology for the synthesis of carbamates at room temperature and atmosp
Riemer, Daniel,Hirapara, Pradipbhai,Das, Shoubhik
p. 1916 - 1920
(2018/08/17)
Palladium-catalyzed intramolecular reductive cross-coupling of Csp 2-Csp3 bond formation
A Pd-catalyzed efficient reductive cross-coupling reaction without metallic reductant to construct a Csp2-Csp3 bond has been reported. A PdIV complex was proposed to be a key intermediate, which subsequently went through d
The present invention relates to allosteric binding compounds of formula (I), especially for the treatment of CNS disorders, together with pharmaceutical compositions and methods of treatment including these compounds.
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Page/Page column 25-26
(2012/04/23)
INHIBITION OF BACTERIAL BIOFILMS WITH ARYL CARBAMATES
Disclosure is provided for carbamate compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.
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Page/Page column 33
(2012/02/01)
ALLOSTERIC BINDING COMPOUNDS
The present invention relates to allosteric binding compounds of formula (I), especially for the treatment of CNS disorders, together with pharmaceutical compositions and methods of treatment including these compounds.
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Page/Page column 69
(2010/09/17)
Mild and selective deprotection of carbamates with Bu4NF
A new mild method allowing the removal of carbamates using TBAF in THF is reported. Reactions were performed on indole, indoline, N-methyl aniline, aniline and tryptamine derivatives. The observed selectivity according to the carbamates or the substrates is discussed. A mechanism is postulated. Graphical Abstract