- Highly enantioselective synthesis of cyclic and functionalized α-amino acids by means of a chiral phase transfer catalyst
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The chiral quaternary ammonium salt 1 serves as phase transfer catalyst for the enantioselective conversion of the glycine derivative 2 to a variety of cyclic and acyclic chiral α amino acids with enantioselectivities as high as 200:1 in alkylation and Michael addition reactions.
- Corey,Noe, Mark C,Xu, Feng
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p. 5347 - 5350
(2007/10/03)
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- DESIGN OF STEREOSPECIFIC INHIBITORS FOR CRYSTAL DISSOLUTION
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A new class of monomeric and polymeric crystal dissolution inhibitors has been prepared taking into consideration the packing arrangements and the morphologies of organic crystals.The efficiency of these inhibitors has been demonstrated by comparative morphological studies of α-glycine and by the kinetic resolution of the racemic conglomerates of his*HCl*H2O, threonine, glu*HCl, and 2,4-sec-phenetyl-3,5-dinitrobenzoate.
- Shimon, L. J. W.,Zbaida, D.,Addadi, L.,Leiserowitz, L.,Lahav, M.
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p. 199 - 222
(2007/10/02)
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