- METHOD FOR PRODUCING P-NITROPHENYL SULFATE
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PROBLEM TO BE SOLVED: To provide a method for producing a p-nitrophenyl sulfate (PNPS salt) such as potassium p-nitrophenyl sulfate (PNPS-K). SOLUTION: A p-nitrophenyl sulfate is produced by reacting p-nitrophenol (PNP) with sulfur trioxide complex in a medium having a low capacity of dissolving p-nitrophenyl sulfate such as tetrahydrofuran, and neutralizing the reaction product with tert-butoxy salt. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
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Paragraph 0043; 0046
(2017/12/27)
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- Ground state structures of sulfate monoesters and sulfamates reveal similar reaction coordinates for sulfuryl and sulfamyl transfer
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Structure/reactivity and structure/structure correlations of 5 sulfate monoesters and 11 sulfamate esters determined by low temperature X-ray crystallography reveal similar ground state deformations that suggest similar reaction coordinates for sulfuryl and sulfamyl group transfer. The Royal Society of Chemistry 2006.
- Denehy, Emma,White, Jonathan M.,Williams, Spencer J.
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p. 314 - 316
(2008/02/08)
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- 34S Isotope Effect on Sulfate Ester Hydrolysis: Mechanistic Implications
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In this communication, we report the first determination of 34S kinetic isotope effects (KIEs) for the hydrolysis of sulfate monoesters. The method involves the conversion of the inorganic sulfate, acquired at partial extent of reaction, to SO2, followed by isotope ratio determination by mass spectrometry. The KIEs determined for p-nitrophenyl sulfate and p-acetylphenyl sulfate are 1.0154 (±0.0002) and 1.0172 (±0.0003), respectively. These results, together with previous peripheral 18O KIE values, are inconsistent with an associative mechanism. The isotope effect method we report should also prove useful for studying the mechanism of other sulfuryl group transfers, including sulfatase and sulfotransferase reactions, as well as sulfate hydrolyses under other conditions. Copyright
- Burlingham, Benjamin T.,Pratt, Lisa M.,Davidson, Ernest R.,Shiner Jr., Vernon J.,Fong, Jon,Widlanski, Theodore S.
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p. 13036 - 13037
(2007/10/03)
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- The Synthesis of p-Nitrophenyl Sulphate
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The procedure for the synthesis of p-nitrophenyl sulphate, a substrate for arylsulphatase activity estimation, has been described.
- Marzec, Krzysztof,Gniot-Szulzycka, Jadwiga
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p. 371 - 373
(2007/10/02)
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