- Concise Total Synthesis of Herqulines B and C
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A simple total synthesis of herqulines B and C is reported, modeled on the reductive biosynthesis reported previously by other researchers. Commencing from tyrosine, these alkaloids were fashioned through a dimerization, macrocyclization, and four consecu
- He, Chi,Stratton, Thomas P.,Baran, Phil S.
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supporting information
p. 29 - 32
(2019/01/16)
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- Scalable Synthesis of Mycocyclosin
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We report herein the scalable total synthesis of the secondary metabolite, mycocyclosin, initially isolated from Mycobacterium tuberculosis. Mycocylosin bears a highly strained 3,3′-dityrosine biaryl system which arises biosynthetically from an intramolec
- Zhu, Xu,McAtee, Christopher C.,Schindler, Corinna S.
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supporting information
p. 2862 - 2866
(2018/05/29)
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- COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY
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The present invention relates to the use of compounds of the following general formula (I): wherein no is 0 or 1, and when no is 1, X = CH2 or X = NCH2C6H5; R1 is OH, or a OR10 group, or a group of formula NH-(CH2)n1-R11; R2 is H, or an alkyl group, or a group of formula (CH2)n2-(CO)n3-NR13R14; R3 is H, or an alkyl group; R4 is H, or Boc, or Z; R5 is H, or Boc, or Z ; R6 is a OR16 group; R7 and R8 are H, or a halogen atom, as modulators of the proteasome activity, in the frame of the preparation of a medicament useful for the prevention or treatment of diseases wherein the proteasome is involved, or the preparation of cosmetic compositions, or of phytosanitary compositions.
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Page/Page column 80
(2008/06/13)
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- Synthesis of the (S,S,S)-diastereomer of the 15-membered biaryl ring system of RP 66453
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The synthesis of the 15-membered biaryl ring system constituting an appropriately functionalized AB ring system of RP 66453 is detailed.
- Krenitsky, Paul J.,Boger, Dale L.
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p. 4019 - 4022
(2007/10/03)
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