- [4 + 2] Cycloadditions of rigid s-cis dienes to C60. A synchronous Diels-Alder reaction
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(Matrix presented) The Diels-Alder reaction of rigid s-cis dienes with C60 occurs by a concerted mechanism, via a symmetrical transition state.
- Chronakis, Nikos,Orfanopoulos, Michael
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p. 545 - 548
(2007/10/03)
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- Efficient in-situ redox catalytic NAD(P)+ regeneration in enzymatic synthesis using transition-metal complexes of 1,10-phenanthroline-5,6-dione and its N-monomethylated derivative as catalysts
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In comparative studies, we have been able to demonstrate that redox catalysts based on transition-metal complexes using 1,10-phenanthroline-5,6-dione as a ligand or based on N-methylated 1,10-phenathroline-5,6-dione acting via hydride ion abstraction are superior to alternative methods for the redox catalytic aerobic or indirect electrochemical in situ NAD(P)+ regeneration in enzymatic syntheses using alcohol dehydrogenases as production enzymes. Under preparative conditions in the gram scale we were able to obtain turnover frequencies of up to 130 turnovers per hour with respect to the redox catalyst. These are far larger than those of the presently most popular regeneration system. Wiley-VCH Verlag GmbH, 1997.
- Hilt, Gerhard,Lewall, Burhanshah,Montero, Guillermo,Utley, James H. P.,Steckhan, Eberhard
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p. 2289 - 2296
(2007/10/03)
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- Synthesis of Four Chiral Pharmaceutical Intermediates by Biocatalysis
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Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of four pharmaceutical drug candidates.These include: (i) the microbial reduction of 3,5-dioxo-6-(benzyloxy) hexanoic ethyl ester to (3S,5R)-dihydroxy-6-(benzyloxy) he
- Patel, Ramesh N.,Banerjee, Amit,Szarka, Laszlo J.
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p. 1247 - 1264
(2007/10/03)
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- Enzymes in organic synthesis. 32. Stereospecific horse liver alcohol dehydrogenase-catalyzed oxidations of exo- and endo-oxabicyclic meso diols
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Preparative-scale horse liver alcohol dehydrogenase-catalyzed oxidation of meso exo- and endo-7-oxabicycloheptane diols provides a direct one-step route to enantiomerically pure chiral γ-lactones of the oxabicyclic series.
- Jones, J. Bryan,Francis, Christopher J.
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p. 2578 - 2582
(2007/10/02)
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- Synthesis of thromboxane A2 analogue (+/-)-(9,11),(11,12)-dideoxa-(9,11a)-oxa thromboxane A2
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A synthesis of the thromboxane A2 analogue, (+/-)-(9,11),(11,12)-dideoxa-(9,11a)-oxa-thromboxane A2 (TXA2) starting from the exo-adduct 3 of maleic anhydride and furan is described
- Kametani, Tetsuji,Suzuki, Toshio,Tomino, Akiko,Kamada, Shinko,Unno, Katsuo
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p. 905 - 908
(2007/10/02)
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- 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
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New 7-oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs which have the general formula STR1 wherein R1 is hydrogen or lower alkyl; n is 0 to 4, m is 0 to 4 and x is 0 to 8, are useful as cardiovascular agents.
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- A SIMPLE SYNTHESIS OF BICYCLOHEPTANE SYSTEM,A KEY POTENTIAL INTERMEDIATE FOR STABLE PROSTAGLANDIN H2 ANALOGUE
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A simple and efficient synthesis of 6-cyanomethyl-1-methoxycarbonylbicycloheptane system leading to stable prostaglandin H2 analogue is described.
- Suzuki, Toshio,Tomino, Akiko,Matsuda, Yasuyuki,Unno, Katsuo,Kametani Tetsuji
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p. 1735 - 1738
(2007/10/02)
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- 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
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New 7-oxabicycloheptane- and 7-oxabicycloheptene compounds which have the general formula STR1 and intermediates therefor which have the general formulas STR2 are useful as cardiovascular agents.
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