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62568-57-4

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Antioxidant and detoxifying activities of analogues of the delta sleep inducing peptide
Sixteen peptides differing in structure from the delta sleep inducing peptide (DSIP) by one to two substitutions of amino acid residues have been synthesized to study the possibility of their application in oncology. The antioxidant properties of the peptides in vitro and their detoxifying activity in vivo have been examined on a model of toxicosis caused by cisplatin, a cytostatic drug widely used in the therapy of tumor diseases. It has been shown that almost all DSIP analogues examined exhibit a direct antioxidant activity, with the activity of the ID-6 analogue being higher than that of DSIP and comparable with that of vitamin C and β-carotene. This analogue shows the most pronounced detoxifying activity toward the action of cisplatin, which manifests itself as a decrease in the death of animals from acute toxicity to 17% compared to 50-67% in the control and the restoration of some biochemical parameters of blood, in particular, a decrease in the activity of the enzymes, aspartate and alanine aminotransferases, and the concentration of the end products of nitrogen exchange: creatinine and urea. Thus, the peptides of the DSIP family may appear promising agents for decreasing the toxic effects of cytostatics used in oncology.
Mikhaleva,Ivanov,Onoprienko,Prudchenko,Chikin,Yakubovskaya,Nemtsova,Bezborodova
p. 1 - 8
(2014)
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One-pot liquid-phase synthesis of DSIP and 5-phe-DSIP using fluoren-9-yl-methoxycarbonyl-protected amino acid pentafluorophenyl esters
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Wang,Xu
p. 845 - 846
(2007/10/02)

NATURAL PEPTIDES AND THEIR ANALOGS. XXXIV. SYNTHESIS OF DELTA-PEPTIDE AND ITS STRUCTURAL ANALOGS
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Ryabtsev, M. N.,Funtova, S. M.,Zuyanova, T. I.,Shvachkin, Yu. P.
p. 394 - 399
(2007/10/02)

Rapid peptide synthesis in liquid phase. Preparation of angiotensin II and delta-sleep-inducing peptide by the 'hold-in' solution method
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Nozaki,Muramatsu
p. 2165 - 2168
(2007/10/02)

SYNTHESIS OF THE δ-SLEEP PEPTIDE AND SOME OF ITS ANALOGS
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Kalikhevich, V. N.,Churkina, S. I.,Martynov, V. F.
p. 1690 - 1695
(2007/10/02)

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Chemical Properties

Boiling Point: 1522.7 °C at 760 mmHg
Flash Point:874.7 °C
Density: 1.458 g/cm³
Storage Temp.:−20°C
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.612
PKA: 3.18±0.10(Predicted)
PSA: 406.74000
LogP: -1.90600

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