- Simple one-pot conversion of alcohols into nitriles
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Various benzylic and primary alcohols were efficiently converted into the corresponding nitriles in good yields at room temperature by treatment with tert-butyl hypochlorite, diiodine, or 1,3-diiodo-5,5-dimethylhydantoin in the presence of (2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl (TEMPO), followed by treatment with diiodine and aqueous ammonia. The nitriles were obtained in good yields and high purities simply by extraction of the reaction mixture with chloroform and subsequent removal of the solvent.
- Shimojo, Hiroyuki,Moriyama, Katsuhiko,Togo, Hideo
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p. 2155 - 2164
(2013/08/23)
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- Pyrimidine derivatives
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This invention provides novel insecticidally and acaricidally active pyrimidine derivatives of formula (I): and stereoisomers thereof, wherein, R1 is selected from alkyl; alkenyl; alkynyl; haloalkyl; haloalkenyl; and cycloalkyl optionally substituted by a
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- TRIMETHYLSILYL CYANIDE PROMOTED CYANATION OF TERTIARY ALKYL CHLORIDES AND OTHER SN1 ACTIVE COMPOUNDS
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Tertiary chlorides are readily cyanated in a one-pot procedure using trimethylsilyl cyanide in the presence of SnCl4.The mechanism of this novel and synthetically useful reaction involves initial isonitrile formation followed by rearrangement to the tertiary nitrile.Other SN1 active compounds also undergo smooth cyanation.
- Reetz, Manfred T.,Chatziiosifidis, Ioannis,Kuenzer, Hermann,Mueller-Starke, Hans
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p. 961 - 966
(2007/10/02)
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- Direct One-Step Conversion of Alcohols into Nitriles
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Alcohols are converted into nitriles in good to excellent yields by treatment with 2 equiv of NaCN/Me3SiCl and a catalytic amount of NaI in DMF/CH3CN.
- Davis, Roman,Untch, Karl G.
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p. 2985 - 2987
(2007/10/02)
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