- A different role of Meldrum's acid in the Biginelli reaction
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A Biginelli-type condensation using Meldrum's acid has been accomplished in refluxing AcOH to give 6-substituted dihydropyrimidine-2,4-(1H,3H)-diones. In contrast to other aldehydes, the three-component reaction with salicylaldehyde led to an oxygen-bridged pyridine. A reaction mechanism is proposed.
- Svetlik, Jan,Veizerova, Lucia
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experimental part
p. 199 - 205
(2011/04/17)
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- DIHYDROURACIL COMPOUNDS AS ANTI-ICTOGENIC OR ANTI-EPILEPTOGENIC AGENTS
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Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent or treat ictogenesis, epileptogenesis, or epileptogenesis-associated conditions. Methods for preparing the compounds of the invention are also described. Particularly preferred compounds of the invention include Formula 1 as described herein.
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- THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS
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The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.
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- Synthesis and evaluation of anticonvulsant activities of some new arylhexahydropyrimidine-2,4-diones
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In this study, some new 3-alkyl-6-arylhexahydropyrimidine-2,4-dione derivatives were synthesized as anticonvulsant agents. 6-Arylhexahydropyrimidine-2,4-diones which were used as starting materials in the synthesis of the compounds were prepared in acidic
- Calis,Koeksal
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p. 523 - 528
(2007/10/03)
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- Thermal reaction of cinnamic acid and of β-styrylphosphonic acid with urea
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The thermal reaction of b-styrylphosphonic acid under experimental conditions similar to those applied to cinnamic acid and to methyl cinnamate to provide 6-phenyl-5,6-dihydrouracil, led to the formation of the novel 6-phenyl-5,6-dihydro-4-phosphorylamide-(1H,3H)-2-pyrimidinone.
- Vuano,Pieroni,Cabaleiro
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p. 318 - 320
(2007/10/03)
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- A New Route to 5,6-Dihydropyrimidin-4(3H)-ones
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The addition reaction of 2,4-bis(methylthio)pyrimidine or 2,4-dimethoxypyrimidine with organolithium reagents produces unstable 6-substituted 2,4-bis(methylthio)-5,6-dihydropyrimidines and 2,4-dimethoxy-5,6-dihydropyrimidines, respectively.The regioselect
- Strekowski, Lucjan,Watson, Rebecca A.,Faunce, Michelle A.
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p. 579 - 581
(2007/10/02)
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