- PYRIMIDONE DERIVATIVES CONTAINING TWO FUSED BICYCLIC RINGS
-
The invention relates to a compound of formula (I), wherein the variables are defined in the specification. It also relates to a pesticidal mixture comprising the compound of formula (I); the use of compounds of formula (I) as an agrochemical pesticide; a method for combating or controlling invertebrate pests, a method for protecting growing plants from attack or infestation by invertebrate pests, seed comprising a compound of the formula (I); the use of a compound of the formula (I) for protecting growing plants from attack or infestation by invertebrate pests; and a method for treating or protecting an animal from infestation or infection by invertebrate pests.
- -
-
Page/Page column 133
(2021/05/29)
-
- VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL INHIBITOR
-
A compound represented by the following General Formula (I), a tautomer or a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, is used as a voltage-dependent T-type calcium channel blocker: wherein A represents a fused ring which may have a substituent, the fused ring being composed of a 5-membered heteroaryl group or a 5-membered or 6-membered heterocyclic ring and a benzene ring or the like, the 5-membered heteroaryl group having one to three identical or different heteroatoms as a ring-constituting element(s) having at least one substituent such as an alkoxy group having 1 to 8 carbon atoms and substituted with 1 to 5 halogen atoms; R represents a hydrogen atom or the like; B represents CR5(Q1) or NQ2, herein Q1 represents a benzimidazole group which may have a substituent; Q2 represents an alkyl group having 1 to 8 carbon atoms which may have a substituent, a heteroaryl group which may have a substituent, or the like; R0, R1, R2, R3, R4, and R5 each represent a hydrogen atom or the like; and n and m each represent 0, 1, or 2, provide that n and m are not 0 and 2 at the same time.
- -
-
Paragraph 0224
(2018/12/04)
-
- Inhibitor HBSC11 for hepatitis B virus targeted human La protein and derivative and application thereof
-
The invention belongs to the field of pharmaceuticals and relates to an inhibitor taking human La protein as a target and anti-hepatitis-B-virus effect of a derivative thereof. Through structural modification of the inhibitor taking the human La protein as the target, a human La protein targeted inhibiting compound shown as a formula (I) is obtained by screening. Experiments verify that the compound has high antiviral activity, has La protein targeting effect, can be used for druggability study of new drug resistant to hepatitis B virus and is expected to be developed into new non-nucleoside anti-HBV drug.
- -
-
Paragraph 0044; 0045
(2018/06/05)
-
- SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS
-
The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
- -
-
-
- 1,3-Dipolar Addition of Pyridine N-Imine to Acetylenes and the Use of C-13 NMR in Several Structural Assignments
-
Addition of pyridine-N-imine to a variety of acetylenic mono- (Scheme I) and di- (Scheme II) carboxylic ester dipolarophiles was carried out.Several of the 3-azapyrrocoline esters obtained were further converted into acids, amides and hydrazides as shown in Schemes I and II.
- Anderson, Paul L.,Hasak, James P,Kahle, Alicia D.,Paolella, Nicholas A.,Shapiro, Michael J.
-
p. 1149 - 1152
(2007/10/02)
-