- Synthesis and structure-activity relationships of juvenoids derived from 2-(4-hydroxybenzyl)cycloalkan-1-ones
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Juvenoids 16-30, 32, 36, 38-41, 44-46, and 49-56 containing carbamate, carbonate, and urea moieties in the molecule were synthesized and subjected to a biological screening. Carbamate juvenoids 1-4 were used as reference compounds for a detailed structure-activity study of their analogues. A clear relationship between the nature of the side chain functional group and the biological activity was found. Surprisingly, not only the juvenoids 1,4 but also 38-41, the compounds with a reversed carbamate N,O-substitution pattern, showed very promising biological activity. In contrast, the carbonate and urea derivatives displayed a remarkably low activity. The relationship between the size and substitution at atoms C(2) and C(3) of the saturated ring and the biological activity is very complex and is still not completely understood.
- Rejzek,Wimmer,Saman,Ricankova,Nemec
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p. 1241 - 1255
(2007/10/02)
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- Disperse dyes which are convertible into a thermo-migration fast form
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The dyes according to the invention consist of a chromophore and a radical which, on heating, forms an isocyanate or isothiocyanate group. The latter reacts with a suitable group in the environment. Dyeings of excellent thermomigration fastness are obtained. The disclosed dyes are of the formulae STR1 where F is the radical of an azo, anthraquinone or tricyanovinyl dye which is free of water-solubilizing groups, B and B' are each independently of the other a direct bond or a bridge member, selected from the group consisting of a straight-chain or branched alkylene group having 2 to 8 C atoms or one of the following groups STR2 where R is hydrogen or C1 -C6 alkyl, n is an integer from 1 to 8 and m is an integer from 2 to 4, Z is O or S, V is a group which at a temperature between 180° and 240° C. is eliminated as a radical HV, and V' is a direct bond which is cleaved at a temperature between 180° and 240° C. or is a group which at such temperature turns, by ring opening and cleavage of the bond V'-C, into a group V'H, with the provisos that in the azo dyes the diazo component is not aminobenzisothiazole and the coupling component is not N-(β-phenylureidoethyl)-1-naphthylamine when the diazo component is 2,4-dinitro-6-bromoaniline.
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