cas 63484-12-8, Methyl 2-methoxy-5-methylsulfonylbenzoate

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SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPANES USEFUL FOR THE TREATMENT ALLERGIC DISEASES
The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4] diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
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(2008/06/13)

Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
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(2008/06/13)

Novel substituted 4-(1H-benzimidazol-2-yl) [1,4]diazepanes useful for the treatment of allergic diseases
The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
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(2008/06/13)

Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
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(2008/06/13)

Chemical Properties

Appearance/Colour :yellowish fine powder
Melting Point: 117 °C
Boiling Point: 396.7oC at 760 mmHg
Flash Point:167.6oC
Density: 1.126 g/cm3
Solubility:DMSO (Slightly), Methanol (Slightly)
Storage Temp.:Sealed in dry,Room Temperature
Vapor Pressure: 1.41E-07mmHg at 25°C
PSA: 78.05000
LogP: 1.96610

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63484-12-8

Articles about 63484-12-8Total 4 be found

Chemical Properties

Appearance/Colour :yellowish fine powder

Melting Point: 117 °C

Boiling Point: 396.7oC at 760 mmHg

Flash Point:167.6oC

Density: 1.126 g/cm3

Solubility:DMSO (Slightly), Methanol (Slightly)

Storage Temp.:Sealed in dry,Room Temperature

Vapor Pressure: 1.41E-07mmHg at 25°C

PSA: 78.05000

LogP: 1.96610

Global suppliers and manufacturers of 63484-12-8total 59 suppliers on LookChem