Compounds of the general structure A and B were investigated for their activity as lipoprotein(a), [Lp(a)], assembly (coupling) inhibitors. SAR around the amino acid derivatives (structure A) gave compound 14-6 as a potent coupling inhibitor. Oral dosing
Sexton, Karen E.,Lee, Helen T.,Massa, Mark,Padia, Janak,Patt, William C.,Liao, Peggy,Pontrello, Jason K.,Roth, Bruce D.,Spahr, Mark A.,Ramharack, Randy
p. 4827 - 4845
(2007/10/03)
Phenyl glycine compounds and methods of treating atherosclerosis and restenosis
The present invention provides compounds having the Formula I The present invention also provides methods of treating atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compositions comprising the
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(2008/06/13)
Alkylation of 2,6-Di-tert-butylphenol with Ethyl Bromoacetate
The ratio of C- and O-alkylation products in the reactions of potassium and sodium 2,6-di-tert-butylphenoxides with ethyl bromoacetate is determined by the nature of the ester group, alkali metal, and solvent.
Titova, T. F.,Krysin, A. P.
p. 61 - 63
(2007/10/03)
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