Horseradish peroxidase transforms morphinane alkaloids into N-oxides and morphine to pseudomorphine in the presence of hydrogen peroxide.The crude poppy enzyme fraction shows the same activities.The rates of reactions were influenced by phenolic compounds and their relation controlled by the concentration of hydrogen peroxide and the presence of ascorbic acid. - Key Word Index: Papaver somniferum; Papaveraceae; morphine; codeine; thebaine; morphinane N-oxides; pseudomorphine; peroxidase; poppy enzyme fraction; phenolcarboxylic acids; ascorbic acid.
Vagujfalvi, Dezsoe,Petz-Stifter, Maria
p. 1533 - 1536
(2007/10/02)
A note on the effects of 2,4-diamino-5-phenylthiazole and 1, 2, 3, 4-tetrahydro-9-aminoacridine on morphine metabolism.
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Woo,Gaff,Fennessy
p. 763 - 767
(2007/10/07)
Preparation and pharmacological investigation of N-oxides of opium alkaloids.