cas 64-75-5, Tetracycline hydrochloride | Articles data ｜lookchem

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64-75-5

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PENTACYCLINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetra-cycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.
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Paragraph 0196-0197

(2020/07/02)

SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
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Page/Page column 106-107

(2008/06/13)

Tetracycline compositions
Aqueous solutions of tetracycline or salts thereof, a pharmaceutically acceptable soluble magnesium compound and 2-pyrrolidone as a co-solvent, said solution having a pH of 7.5 to 9.5 and being useful as an injectable composition combining low viscosity, high potency, good clarity and good stability.
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(2008/06/13)

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Chemical Properties

Appearance/Colour :Yellow crystalline powder
Melting Point: 220-223 °C(lit.)
Boiling Point: 799.4 °C at 760 mmHg
Flash Point:437.3 °C
Solubility:H2O: 10 mg/mL as a stock solution. Stock solutions should b
Storage Temp.:2-8°C
Vapor Pressure: 5.82E-27mmHg at 25°C
Refractive Index: -253 ° (C=0.5, 0.1mol/L HCl)
Sensitive: Air & Light Sensitive
Merck: 14,9196
BRN: 3844873
PSA: 181.62000
LogP: 1.28790

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