- Selective Rhodium-Catalyzed Hydroformylation of Terminal Arylalkynes and Conjugated Enynes to (Poly)enals Enabled by a π-Acceptor Biphosphoramidite Ligand
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The hydroformylation of terminal arylalkynes and enynes offers a straightforward synthetic route to the valuable (poly)enals. However, the hydroformylation of terminal alkynes has remained a long-standing challenge. Herein, an efficient and selective Rh-catalyzed hydroformylation of terminal arylalkynes and conjugated enynes has been achieved by using a new stable biphosphoramidite ligand with strong π-acceptor capacity, which affords various important E-(poly)enals in good yields with excellent chemo- and regioselectivity at low temperatures and low syngas pressures.
- Zhao, Jiangui,Zheng, Xueli,Tao, Shaokun,Zhu, Yuxin,Yi, Jiwei,Tang, Songbai,Li, Ruixiang,Chen, Hua,Fu, Haiyan,Yuan, Maolin
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supporting information
p. 6067 - 6072
(2021/08/16)
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- Synthesis of perspicamide A and related diverse analogues: Their bioevaluation as potent antileishmanial agents
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The first protocol for the synthesis of perspicamide A and related diverse analogues has been developed from economical and readily available starting materials. Furthermore, a few synthesized analogues, 24a, 24b, 24c, 24d, and 24l, exhibited potent activ
- Pandey, Anand Kumar,Sharma, Rashmi,Shivahare, Rahul,Arora, Ashish,Rastogi, Neeraj,Gupta, Suman,Chauhan, Prem M. S.
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p. 1534 - 1546
(2013/04/10)
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- Stereoselective synthesis of (E)-β-arylvinyl bromides by microwave-induced Hunsdiecker-type reaction
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(E)-β-Arylvinyl bromides were readily prepared in a short reaction time (1-2 min) by microwave irradiation of the corresponding 3-arylpropenoic acids in the presence of N-bromosuccinimide and a catalytic amount of lithium acetate. Furthermore, two facile strategies for the efficient synthesis of (E)-β-bromo-4-arylethynylstyrene and (E)-β-bromo-4-arylstyrene have been developed by respectively combining Sonogashira and Suzuki coupling reaction with Hunsdiecker-type reaction. Formation of cis-α-bromo-β- lactone by microwave irradiation of cis-cinnamic acid with NBS provides a useful support for the mechanistic study of the present halodecarboxylation reaction. Georg Thieme Verlag Stuttgart.
- Kuang, Chunxiang,Yang, Qing,Senboku, Hisanori,Tokuda, Masao
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p. 1319 - 1325
(2007/10/03)
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- A new and facile method for stereoselective synthesis of (E)-styryl bromides by the reduction of 1,1-dibromoalkenes using LiAlH4-EtOAc (1:1)
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A facile method for stereoselective synthesis of (E)-styryl bromides by the reduction of 1,1-dibromoalkenes using LiAlH4-EtOAc (1:1) is described. We believe that the present procedure is a good alternative to the Tokuda's microwave method with good stereoselectivity.
- Horibe, Hideo,Kondo, Kazuhiro,Okuno, Hiroaki,Aoyama, Toyohiko
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p. 986 - 988
(2007/10/03)
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