- Synthesis and biological activity of novel 2,5-disubstituted-l,3,4- oxadiazoles
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A new and previously unreported molecular framework of 1,3,4-oxadiazoles incorporating halo pyridines has been synthesised. The derivatives are synthesised starting from substituted pyridinyloxy benzaldehydes, by converting them in to corresponding arylidene hydrazides followed by chloramine-T oxidation to the title compounds. The 2,5-disubstituted 1,3,4- oxadiazole derivatives are tested for antimicrobial activity. Many compounds showed high degree of activity against Staphylococus aureus and Escherichia coli bacteria at 250 μg/mL concentration.
- Shailaja,Anitha,Manjula,Rao, B. Vittal
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experimental part
p. 1088 - 1097
(2010/10/21)
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- ESTER DERIVATIVES OF (PYRIDINYLOXY-PHENYL)-METHANOL AND PROCESS OF PREPARATION THEREOF
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The present invention relates to novel pyridinyloxy phenyl methanol derivatives of the formula (III) with X=(a) or (b), obtained by the reaction of 4-/3-(3,5,6-pyridinyl-2-oxy)phenylmethanol and 4-/3-(2,3,5,6-pyridinyl-4-oxy)phenyl methanol with the acid
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- Oxidative deoximation with catalytic sodium tungstate
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A simple and mild method of oxidative deoximation based on catalytic amount of sodium tungstate is described. This method is effective for deprotection of ketones and aldehydes.
- Manjula,Reddy, G. Narsimha,Vittal Rao
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p. 3455 - 3459
(2007/10/03)
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