Toluene and its Derivatives as Atom-Efficient Benzylating Agents for Secondary Amines
Toluene as a replacement for common N -benzylating agents, such as benzyl bromide, can be an atom-efficient alternative reagent. Under nickel catalysis and mildly oxidative conditions, it is possible to activate toluene efficiently and use it directly for the benzylation of different 2-aminopyridines. The transformation is not restricted to simple toluene, but also substituted derivatives give the desired product in good yields. Effective cleavage of the pyridine moiety is presented.
Sch?nbauer, David,Lukas, Florian,Schnürch, Michael
supporting information
p. 94 - 98
(2019/01/04)
More Articles about upstream products of 6456-92-4