A general synthetic method for the formation of substituted 5-aminotetrazoles from thioureas: a strategy for diversity amplification.
A general method for the synthesis of 5-aminotetrazoles is outlined using the mercury(II)-promoted attack of azide anion on a thiourea. The reaction proceeds through a guanyl azide intermediate, which undergoes electrocyclization to the tetrazole. The method is high yielding and provides access to mono-, di-, and trisubstituted 5-aminotetrazoles, targets of potential interest for combinatorial library development.
Batey,Powell
p. 3237 - 3240
(2007/10/03)
Synthesis of N-Allyl-2-oxocycloalkanecarbothioamides, Functionalised Organic Intermediates via Enamines
Cyclopent-1-enylmorpholine (1a)/pyrrolidine (1b) and cyclohex-1-enylpyrrolidine (1c)/aniline (1d) with allyl isothiocyanate furnish N-allyl-2-oxo-cyclopentane- and N-allyl-2-oxocyclohexanecarbothioamides (3,n = 3/4), respectively after hydrolysis of the product mixture.
Singh, Harjit,Singh, Paramjit,Mehta, R. K.
p. 1048 - 1049
(2007/10/02)
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