- Dual Role of Oxoaldehydes: Divergent Synthesis of 3-Aryl- and 3-Aroylcoumarins
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A facile and efficient synthetic approach to various valuable 3-aryl- and 3-aroylcoumarins by the direct arylation and aroylation of coumarins with glyoxals in a metal-free manner is presented. The aryl glyoxal is for the first time recognized to serve as an aryl surrogate in addition to its role as an aroyl transfer reagent via a simple switch in reaction conditions. The approach accommodates a broad substrate scope and high yields of the two types of cross-coupling reactions starting from identical starting materials.
- Moazzam, Ali,Khodadadi, Meysam,Jafarpour, Farnaz,Ghandi, Mehdi
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p. 3630 - 3637
(2022/02/16)
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- 7-Hydroxycoumarins Are Affinity-Based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor
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Macrophage migration inhibitory factor (MIF) is a cytokine with key roles in inflammation and cancer, which qualifies it as a potential drug target. Apart from its cytokine activity, MIF also harbors enzyme activity for keto-enol tautomerization. MIF enzymatic activity has been used for identification of MIF binding molecules that also interfere with its biological activity. However, MIF tautomerase activity assays are troubled by irregularities, thus creating a need for alternative methods. In this study, we identified a 7-hydroxycoumarin fluorophore with high affinity for the MIF tautomerase active site (Ki = 18 ± 1 nM) that binds with concomitant quenching of its fluorescence. This property enabled development of a novel competition-based assay format to quantify MIF binding. We also demonstrated that the 7-hydroxycoumarin fluorophore interfered with the MIF-CD74 interaction and inhibited proliferation of A549 cells. Thus, we provide a high-affinity MIF binder as a novel tool to advance MIF-oriented research.
- Xiao, Zhangping,Chen, Deng,Song, Shanshan,Van Der Vlag, Ramon,Van Der Wouden, Petra E.,Van Merkerk, Ronald,Cool, Robbert H.,Hirsch, Anna K. H.,Melgert, Barbro N.,Quax, Wim J.,Poelarends, Gerrit J.,Dekker, Frank J.
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p. 11920 - 11933
(2020/11/26)
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- Chlorophyll-catalyzed photochemical regioselective coumarin C-H arylation with diazonium salts
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This communication describes the development of a mild method for the cross-coupling of the C3-position of coumarin with an array of diazonium salts mediated by chlorophyll as a biocatalyst via visible light catalysis. A natural pigment such as chlorophyll is used as a green photosensitizer and environmentally benign catalyst. This general and easy procedure provides a transition-metal-free alternative for the formation of 3-aryl coumarin derivatives at room temperature with good to excellent yields. This journal is
- Moazzam, Ali,Jafarpour, Farnaz
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supporting information
p. 16692 - 16696
(2020/10/27)
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- Antibacterial Activity and Molecular Docking Studies of a Selected Series of Hydroxy-3-arylcoumarins
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Antibiotic resistance is one of the main public health concerns of this century. This resistance is also associated with oxidative stress, which could contribute to the selection of resistant bacterial strains. Bearing this in mind, and considering that f
- Pisano, Maria Barbara,Kumar, Amit,Medda, Rosaria,Gatto, Gianluca,Pal, Rajesh,Fais, Antonella,Era, Benedetta,Cosentino, Sofia,Uriarte, Eugenio,Santana, Lourdes,Pintus, Francesca,Matos, Maria Jo?o
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- 1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1
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A series of coniugates bearing a 1,2,3,4-tetrahydroisoquinoline motif linked to substituted 7-hydroxy-2H-chromen-2-ones was synthesized and assayed through calcein-AM test in Madin-Darby Canine Kidney (MDCK) cells overexpressing P-glycoprotein (P-gp) and closely related multidrug resistance associated protein 1 (MRP1) to probe the interference with efflux mechanisms mediated by P-gp and MRP1, respectively. A number of substituents at C3 and C4 of coumarin nucleus along with differently sized and shaped spacers was enrolled to investigate the effects of focused structural modifications over affinity and selectivity. Linker length and flexibility played a key role in enhancing P-gp affinity as proved by the most potent P-gp modulator (3h, IC50 = 70 nM). A phenyl ring within the spacer (3k, 3l, 3o) and bulkier groups (Br in 3r, Ph in 3u) at coumarin C3 led to derivatives showing nanomolar activity (160 nM 50 350). Molecular docking calculations carried out on a human MDR1 homology model structure contributed to gain insights into the ligands’ binding modes. Some compounds (3d, 3h, 3l, 3r, 3t, 3u) reversed MDR thereby restoring doxorubicin cytotoxicity when co-administered with the drug into MDCK-MDR1 cells.
- Rullo, Mariagrazia,Niso, Mauro,Pisani, Leonardo,Carrieri, Antonio,Colabufo, Nicola Antonio,Cellamare, Saverio,Altomare, Cosimo Damiano
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p. 433 - 444
(2018/10/31)
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- Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents
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A variety of substituted 3-arylcoumarin derivatives were synthesised through microwave radiation heating. The method has characteristics of environmental friendliness, economy, simple separation, and purification process, less by-products and high reaction yield. Those 3-arylcoumarin derivatives were screened for antioxidant, α-glucosidase inhibitory and advanced glycation end-products (AGEs) formation inhibitory. Most compounds exhibited significant antioxidant and AGEs formation inhibitory activities. Anti-diabetic activity studies showed that compounds 11 and 17 were equipotent to the standard drug glibenclamide in vivo. According to the experimental results, the target compound 35 can be used as a lead compound for the development of new anti-diabetic drugs. The whole experiment showed that anti-diabetic activity is prevalent in 3-arylcoumarins, which added a new natural skeleton to the development of anti-diabetic active drugs.
- Hu, Yuheng,Wang, Bing,Yang, Jie,Liu, Teng,Sun, Jie,Wang, Xiaojing
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- 3-Aryl Coumarin Derivatives Bearing Aminoalkoxy Moiety as Multi-Target-Directed Ligands against Alzheimer's Disease
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Two series of novel coumarin derivatives, substituted at 3 and 7 positions with aminoalkoxy groups, are synthesized, characterized, and screened. The effect of amine substituents and the length of cross-linker are investigated in acetyl- and butyrylcholin
- Abdshahzadeh, Helia,Golshani, Mostafa,Nadri, Hamid,Saberi Kia, Iraj,Abdolahi, Zahra,Forootanfar, Hamid,Ameri, Alieh,Tüylü Kü?ükk?l?n?, Tuba,Ayazgok, Beyza,Jalili-Baleh, Leili,Sadat Ebrahimi, Seyed Esmaeil,Moghimi, Setareh,Haririan, Ismaeil,Khoobi, Mehdi,Foroumadi, Alireza
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- Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents
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Alzheimer's disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer's disease. Various substituted 3-arylcoumarin derivatives were synthesised, and their in vitro activity, including cholinesterase inhibitory activity, monoamine oxidase inhibitory activity, and antioxidant activity were investigated. Most of the compounds exhibited high activity; therefore 3-arylcoumarin compounds have the potential as drug candidates for the treatment of Alzheimer's disease.
- Yang, Jie,Zhang, Pingping,Hu, Yuheng,Liu, Teng,Sun, Jie,Wang, Xiaojing
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p. 651 - 656
(2019/02/19)
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- COMPOUNDS CONTAINING SI ATOMS FOR OPTICALLY ACTIVE DEVICES
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The present invention relates to novel 2-oxo-2H-chromen compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic
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- Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds
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A novel series of coumarin-lipoic acid conjugates were synthesized via cycloaddition click reaction to find out new multi-target-directed ligands (MTDLs) for treatment of Alzheimer's disease (AD). All of synthesized compounds were screened for neuroprotec
- Jalili-Baleh, Leili,Forootanfar, Hamid,Kü?ükk?l?n?, Tuba Tüylü,Nadri, Hamid,Abdolahi, Zahra,Ameri, Alieh,Jafari, Mandana,Ayazgok, Beyza,Baeeri, Maryam,Rahimifard, Mahban,Abbas Bukhari, Syed Nasir,Abdollahi, Mohammad,Ganjali, Mohammad Reza,Emami, Saeed,Khoobi, Mehdi,Foroumadi, Alireza
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p. 600 - 614
(2018/06/26)
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- BIS-COMPOUNDS FOR OPTICALLY ACTIVE DEVICES
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The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprisin
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Page/Page column 150
(2018/09/12)
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- HYDROPHOBIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES
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The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprisin
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Page/Page column 129; 130
(2018/09/12)
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- A transition-metal-free fast track to flavones and 3-arylcoumarins
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A highly regioselective and transition-metal free one-pot arylation of chromenones with arylboronic acids has been achieved employing K2S2O8. The procedure consists of a sequence of some reactions including an arylation/decarboxylation cascade and proceeds well in aqueous media to afford biologically interesting flavones and 3-arylcoumarins. This method exhibited excellent selectivity and functional group tolerance under mild conditions. The reaction also showed perfect efficacy for the preparation of styryl coumarins.
- Golshani, Mostafa,Khoobi, Mehdi,Jalalimanesh, Nafiseh,Jafarpour, Farnaz,Ariafard, Alireza
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supporting information
p. 10676 - 10679
(2017/10/06)
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- HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES
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The present invention relates to novel compounds, particularly to hydrophilic compounds, comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices. The present application also relates to ophthalmic devices com
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- Regioselective C-3 arylation of coumarins with arylhydrazines via radical oxidation by potassium permanganate
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An efficient protocol for oxidative C-3 arylation of coumarins with arylhydrazine has been developed using potassium permanganate as an oxidant. The arylated coumarins with different electronic properties were obtained in moderate to good yields. The deve
- Yuan, Jin-Wei,Li, Wei-Jie,Yang, Liang-Ru,Mao, Pu,Xiao, Yong-Mei
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p. 1115 - 1123
(2016/11/16)
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- Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents
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The modulation of the endocannabinoid system is emerging as a viable avenue for the treatment of neurodegeneration, being involved in neuroprotective and anti-inflammatory processes. In particular, indirectly enhancing endocannabinoid signaling to therapeutic levels through FAAH inhibition might be beneficial for neurodegenerative disorders such as Alzheimer's disease, effectively preventing or slowing the progression of the disease. Hence, in the search for a more effective treatment for Alzheimer's disease, in this paper, the multitarget-directed ligand paradigm was applied to the design of carbamates able to simultaneously target the recently proposed endocannabinoid system and the classic cholinesterase system, and achieve effective dual FAAH/cholinesterase inhibitors. Among the two series of synthesized compounds, while some derivatives proved to be extremely potent on a single target, compounds 9 and 19 were identified as effective dual FAAH/ChE inhibitors, with well-balanced nanomolar activities. Thus, 9 and 19 might be considered as new promising candidates for Alzheimer's disease treatment.
- Montanari, Serena,Scalvini, Laura,Bartolini, Manuela,Belluti, Federica,Gobbi, Silvia,Andrisano, Vincenza,Ligresti, Alessia,Di Marzo, Vincenzo,Rivara, Silvia,Mor, Marco,Bisi, Alessandra,Rampa, Angela
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supporting information
p. 6387 - 6406
(2016/07/26)
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- KMnO4/AcOH-mediated C3-selective direct arylation of coumarins with arylboronic acids
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An efficient protocol for KMnO4/AcOH-mediated dehydrogenative direct radical arylation of coumarins with arylboronic acids to afford 3-arylcoumarin derivatives is described. A similar reaction system is also applicable to the 3-arylation of quinolinone derivatives. These KMnO4/AcOH-mediated coupling reactions occur regioselectively at the C3 position of coumarins and quinolinones. Some notable features of this method are high efficiency, moderate to good yield, and a broad group tolerance.
- Yuan, Jin-Wei,Yang, Liang-Ru,Yin, Qiu-Yue,Mao, Pu,Qu, Ling-Bo
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p. 35936 - 35944
(2016/05/19)
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- Synthesis and Biological Evaluation of Fluorinated 3-Phenylcoumarin-7-O-Sulfamate Derivatives as Steroid Sulfatase Inhibitors
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In the present work, we report the initial results of our study on a series of 3-phenylcoumarin sulfamate-based compounds containing C-F bonds as novel inhibitors of steroid sulfatase. The new compounds are potent steroid sulfatase inhibitors, possessing more than 10 times higher inhibitory potency than coumarin-7-O-sulfamate. In the course of our investigation, compounds 2b and 2c demonstrated the highest inhibitory effect on the enzymatic steroid sulfatase assay; both had IC50 values of 0.27 μm (the IC50 value of coumarin-7-O-sulfamate is 3.5 μm, used as a reference).
- Demkowicz, Sebastian,Dako, Mateusz,Kozak, Witold,Krawczyk, Katarzyna,Witt, Dariusz,Maslyk, Maciej,Kubiski, Konrad,Rachon, Janusz
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p. 233 - 238
(2016/02/14)
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- Regioselective α-arylation of coumarins and 2-pyridones with phenylhydrazines under transition-metal-free conditions
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A facile regioselective metal-free direct α-arylation of coumarins and 2-pyridones is achieved by the reaction of coumarins and 2-pyridones with phenylhydrazine in good yields. The reaction proceeds at room temperature under mild conditions using inexpensive reagents and without the need for step intensive activating groups. The methodology is operationally simple, practically viable and also allows the coupling of similar nitrogen heterocycle aza-coumarins without prerequisite N-protection.
- Chauhan, Parul,Ravi, Makthala,Singh, Shikha,Prajapati, Prashant,Yadav, Prem P.
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p. 109 - 118
(2016/01/09)
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- Study of coumarin-resveratrol hybrids as potent antioxidant compounds
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In the present work we synthesized a selected series of hydroxylated 3-phenylcoumarins 5-8, with the aim of evaluating in detail their antioxidant properties. From an in depth study of the antioxidant capacity data (ORAC-FL, ESR, CV and ROS inhibition) it
- Matos, Maria J.,Vazquez-Rodriguez, Saleta,Borges, Fernanda,Santana, Lourdes,Uriarte, Eugenio,Mura, Francisco,Olea-Azar, Claudio
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p. 3290 - 3308
(2015/09/02)
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- Design and discovery of tyrosinase inhibitors based on a coumarin scaffold
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In this manuscript we report the synthesis, pharmacological evaluation and docking studies of a selected series of 3-aryl and 3-heteroarylcoumarins with the aim of finding structural features for the tyrosinase inhibitory activity. The synthesized compounds were evaluated as mushroom tyrosinase inhibitors. Compound 12b showed the lowest IC50(0.19 μM) of the series, being approximately 100 times more active than kojic acid, used as a reference compound. The kinetic studies of tyrosinase inhibition revealed that 12b acts as a competitive inhibitor of mushroom tyrosinase with l-DOPA as the substrate. Furthermore, the absence of cytotoxicity in B16F10 melanoma cells was determined for this compound. The antioxidant profile of all the derivatives was evaluated by measuring radical scavenging capacity (ABTS and DPPH assays). Docking experiments were carried out on mushroom tyrosinase structures to better understand the structure-activity relationships.
- Matos,Varela,Vilar,Hripcsak,Borges,Santana,Uriarte,Fais,Di Petrillo, Amalia,Pintus,Era
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p. 94227 - 94235
(2015/11/17)
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- Color filter comprising Green Dye and Method of manufacturing the same and Display Device using the same
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The present invention relates to a color filter comprising a green dye, a manufacturing method thereof, and a display device using the color filter. The green dye comprises a compound represented in the following chemical formula 1. In the chemical formula 1, M is selected from the group consisting of Zn, Cu, Co, Ni, Fe, and Al. Each from R1 to R12 independently selected from the group consisting of hydrogen, OX, and CY_3, wherein the X is the alkyl group of C_1 to C_20 and the Y is the halogen group.(CC) No baking(BB) Wavelength (nm)(AA) Absorbing rate(FF) Baking at 300anddeg;C(EE) Baking at 200anddeg;C(DD) Baking at 180anddeg;CCOPYRIGHT KIPO 2015
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Paragraph 0038-0042
(2016/12/22)
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- Design and synthesis of ERα/ERβ selective coumarin and chromene derivatives as potential anti-breast cancer and anti-osteoporotic agents
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Several new coumarin and chromene prototype derivatives have been synthesised and evaluated for their ERα and ERβ selective activity. Coumarin prototype compounds 18 & 19 were found to be ERα selective and the most active, exhibiting potential antiproliferative activity against both ER +ve & ER -ve breast cancer cell lines. The surprise finding of the series, however, are the novel prototype III chromenes 45 & 46, with aroyl substitution at the 6th position. Both the compounds have shown potent antiproliferative activity against both the breast cancer cell lines, promote alkaline phosphatase activity, enhance osteoblast mineralization in vitro, significantly decrease ERE-ERα dependent transactivation and induce ERβ activity. This specific upregulation of ERβ isoform activity of compound 45 may be responsible for the antiosteoporotic activity at picomolar concentration. In addition, both the compounds were also devoid of any estrogenic activity, which correlates to their antiestrogenic behaviour in the two breast cancer cell lines. Assessment of selectivity using specific SiRNAs for ERα and ERβ revealed that most of the compounds showed ERα and ERβ-mediated action, except compound 28, which showed selectivity to ERα only. Computational docking analysis of active compounds 18 and 45 was conducted to correlate the interaction with the two receptors and it was found that the docked conformations of the coumarin prototype, compound 18 at ERα and ERβ active sites were more or less superimposable on each other. However, the unique orientation of the aminoalkoxy side chain of novel chromene (prototype III) compound 45 in the ERβ binding cavity may be responsible for its potential biological response. The Royal Society of Chemistry.
- Hussain, M. Kamil,Ansari, M. Imran,Yadav,Gupta, Puneet K.,Gupta,Saxena,Fatima,Manohar,Kushwaha,Khedgikar,Gautam,Kant, Ruchir,Maulik,Trivedi,Dwivedi,Kumar, K. Ravi,Saxena,Hajela
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p. 8828 - 8845
(2014/03/21)
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- Palladium catalyzed dehydrogenative arylation of coumarins: An unexpected switch in regioselectivity
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A new regioselective α-arylation of coumarins with unactivated simple arenes via a palladium-catalyzed twofold C-H functionalization is devised. This method offers an attractive new approach to synthesis of a wide variety of 3-arylcoumarins from readily accessible starting materials. This journal is The Royal Society of Chemistry 2013.
- Jafarpour, Farnaz,Hazrati, Hamideh,Mohasselyazdi, Nazanin,Khoobi, Mehdi,Shafiee, Abbas
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supporting information
p. 10935 - 10937
(2013/11/19)
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- Highly regioselective α-arylation of coumarins via palladium-catalyzed C-H activation/desulfitative coupling
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A novel regioselective α-arylation of coumarins with readily available arenesulfonyl chlorides and sodium arenesulfinates via palladium-catalyzed direct C-H functionalizations under mild reaction conditions is described. This protocol presents an unexpected and highly regio-controlled arylation of coumarins at C-3 to construct interesting 3-arylcoumarins with fascinating biological and fluorescent properties. The regioselectivity observed is in sharp contrast with that expected for the Heck reactions. Copyright
- Jafarpour, Farnaz,Olia, Mina Barzegar Amiri,Hazrati, Hamideh
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supporting information
p. 3407 - 3412
(2013/12/04)
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- 3-phenylcoumarins as inhibitors of HIV-1 replication
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We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Six compounds displayed NF-κB inhibition, four resulted Tat antagonists and three of them showed both activities. Three compounds inhibited HIV replication with IC50 values 25 μM. The antiviral effect of the 4-hydroxycoumarin derivative 19 correlates with its specific inhibition of Tat functions, while compound 8, 3-(2-chlorophenyl) coumarin, seems to act through a mechanism unrelated to the molecular targets considered in this research.
- Olmedo, Dionisio,Sancho, Rocio,Bedoya, Luis M.,Lopez-Perez, Jose L.,Del Olmo, Esther,Munoz, Eduardo,Alcami, Jose,Gupta, Mahabir P.,Feliciano, Arturo San
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p. 9245 - 9257
(2013/01/14)
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- Synthesis and biological evaluation of hydroxylated 3-phenylcoumarins as antioxidants and antiproliferative agents
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Based on the observed biological activities of coumarins and resveratrol, we synthesized fourteen hydroxylated 3-phenylcoumarins (stilbene-coumarin hybrids) including six novel ortho-hydroxy-methoxy substituted derivatives, 1-14, by Perkin reaction. We ch
- Yang, Jie,Liu, Guo-Yun,Dai, Fang,Cao, Xiao-Yan,Kang, Yan-Fei,Hu, Li-Mei,Tang, Jiang-Jiang,Li, Xiu-Zhuang,Li, Yan,Jin, Xiao-Ling,Zhou, Bo
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p. 6420 - 6425
(2011/11/29)
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- Synthesis of flavonoid derivatives of cytisine. 1. Aminomethylation of 7-hydroxy-3-arylcoumarins
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Aminomethylation involving the natural alkaloid (-)-cytisine of analogs of natural 3-arylbenzopyran-2-ones was studied. Substituted 8-(cytisin-12-yl) methyl-3-aryl-7-hydroxycoumarins were synthesized.
- Bondarenko,Frasinyuk,Vinogradova,Khilya
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body text
p. 771 - 773
(2011/02/27)
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- Tyrosinase inhibitor activity of coumarin-resveratrol hybrids
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In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compoun
- Antonella Fais,Corda, Marcella,Era, Benedetta,Fadda, M. Benedetta,Matos, Marioa Joao,Quezada, Elias,Santana, Lourdes,Picciau, Carmen,Podda, Gianni,Delogu, Giovanna
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experimental part
p. 2514 - 2520
(2009/12/06)
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- AN IMPROVED PROCESS FOR THE PREPARATION OF TRANS 3,4- DIARYLCHROMAN AND THEIR DERIVATIVES
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The invention describes an improved and advantageous process of preparation of trans 3,4-diarylchroman and similar derivatives there of, useful as anti-fertility, anti-osteoporotic and breast cancer drugs. Condensation of arenes with 2,2- dialkyl-3-aryl c
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Page/Page column 11
(2009/07/18)
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- Modified coumarins. 29. Synthesis of structural analogs of natural 6-arylfuro[3,2-g]chromen-7-ones
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3-Substituted 6-arylfuro[3,2-g]chromen-7-ones, structural analogs of natural furocoumarins, were synthesized by linear annelation of a furan fragment to a 3-arylcoumarin system.
- Garazd,Garazd,Ogorodniichuk,Khilya
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experimental part
p. 158 - 163
(2009/12/06)
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- Synthesis and binding affinity of 3-aryl-7-hydroxycoumarins to human α and β estrogen receptors
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The synthesis of a set of substituted 3-aryl-7-hydroxycoumarins was performed. The study of the relations between their structure and their relative binding affinity (RBA) to human α and β estrogen receptors was achieved.
- Kirkiacharian,Lormier,Resche-Rigon,Bouchoux,Cérède
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- Conversion of 2-methoxychalcones into 3-phenylcoumarins
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A new approach to the synthesis of 3-phenylcoumarins from 2-methoxychalcone is presented.This conversion constitutes an interesting way of reorganising the central C3-unit of the chalcone.
- Devi, Nirada,Krishnamurty, H. G.
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p. 1187 - 1188
(2007/10/02)
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- A New and Convenient Synthesis of 4-Methyl-3-phenylcoumarins and 3-Phenylcoumarins
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The reaction between ortho-hydroxyacetophenones and phenylacetyl chloride in acetone medium under the influence of potassium carbonate gives 4-methyl-3-phenylcoumarins exclusively.Under identical conditions, aromatic ortho-hydroxyaldehydes yield 3-phenylcoumarins smoothly.The reaction of aromatic ortho-hydroxy-carboxylic acid esters has also been examined.
- Neelakantan, S.,Raman, P. V.,Tinabaye, A.
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p. 256 - 257
(2007/10/02)
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