- A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions
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Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A-C estrogens, lacking the B and D estrogen rings. The
- Hanson, Alicia M.,Perera, K. L. Iresha Sampathi,Kim, Jaekyoon,Pandey, Rajesh K.,Sweeney, Noreena,Lu, Xingyun,Imhoff, Andrea,Mackinnon, Alexander Craig,Wargolet, Adam J.,Van Hart, Rochelle M.,Frick, Karyn M.,Donaldson, William A.,Sem, Daniel S.
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p. 4720 - 4738
(2018/05/23)
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- SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE AND (4'-HYDROXYPHENYL)CYCLOALKENE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM FOR ENHANCED MEMORY CONSOLIDATION
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Disclosed are substituted (4'-hydroxylphenyl)cycloalkane compounds and substituted (4'-hydroxylphenyl)cycloalkene compounds and there use as selective agonists of the estrogen receptor beta isoform (ERβ). The disclosed compounds may be formulated as pharm
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Paragraph 0128; 0166; 0167
(2018/10/25)
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- SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM
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Disclosed are substituted (4'-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (ΕΚβ). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases
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Paragraph 0095; 00133-00134
(2015/06/08)
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- Room Temperature Nematic Photoswitchable Liquid Crystals - Molecular Modularisation of Functional Elements
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The successful design of photochromic self-assembly systems requires understanding (on both the molecular and sub-molecular scales) of diverse and often competing structure-property relationships. Such molecular systems are promising as components for pho
- Frigoli, Michel,Mehl, Georg H.
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p. 636 - 642
(2007/10/03)
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- Organic reaction in water. Part 3: A facile method for reduction of aromatic rings using a Raney Ni-Al alloy in dilute aqueous alkaline solution under mild conditions
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Reduction of aromatic rings such as phenol, naphthalenes, biphenyls, acenaphthene, and acenaphthylene was smoothly performed using a Raney Ni-Al alloy in dilute aqueous alkaline solution without any organic solvents at 90°C under atmospheric pressure, and the corresponding reduced compounds were obtained in high yields. (C) 2000 Elsevier Science Ltd.
- Tsukinoki, Takehito,Kanda, Tadashige,Liu, Guo-Bin,Tsuzuki, Hirohisa,Tashiro, Masashi
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p. 5865 - 5868
(2007/10/03)
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