Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti-Trypanosoma brucei Agents
On the basis of the structure of the CVIM tetrapeptide substrate of mammalian protein farnesyltransferase, a series of imidazole-containing peptidomimetics was designed and synthesized, and their inhibition activity against Trypanosoma brucei protein farn
Ohkanda, Junko,Buckner, Frederick S.,Lockman, Jeffrey W.,Yokoyama, Kohei,Carrico, Dora,Eastman, Richard,De Luca-Fradley, Kate,Davies, Wendy,Croft, Simon L.,Van Voorhis, Wesley C.,Gelb, Michael H.,Sebti, Sa?d M.,Hamilton, Andrew D.
p. 432 - 445
(2007/10/03)
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
Malaria continues to represent a very serious health problem in the tropics. The current methods of clinical treatment are showing deficiencies due to the increased incidence of resistance in the parasite. In the present paper we report the design, synthe
Ohkanda, Junko,Lockman, Jeffrey W.,Yokoyama, Kohei,Gelb, Michael H.,Croft, Simon L.,Kendrick, Howard,Harrell, Maria Isabel,Feagin, Jean E.,Blaskovich, Michelle A.,Sebti, Said M.,Hamilton, Andrew D.
p. 761 - 764
(2007/10/03)
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