Pyrimidopyridone compounds having antitumor activity as well as preparation method and application of pyrimidopyridone compounds
The invention discloses pyrimidopyridone compounds having antitumor activity as well as a preparation method and application of the pyrimidopyridone compounds. The invention particularly discloses thedeuterated pyrimidopyridone compounds represented by a
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Paragraph 0086-0088
(2019/08/20)
Functionalized Helical β-Peptoids
Peptidomimetic foldamers adopting well-defined three-dimensional structures while being stable toward proteolysis are of interest in biomedical research, chemical biology, and biomimetic materials science. Despite their backbone flexibility, β-peptoids containing N-(S)-1-(1-naphthyl)ethyl (Ns1npe) side chains can fold into unique triangular prism-shaped helices. We report herein the successful introduction of amino groups onto robustly folded β-peptoid helices by construction and incorporation of novel chiral building blocks. This is the first example of an X-ray crystal structure of a linear β-peptoid containing more than one type of side chain. We thus present a unique foldamer design comprising a robustly folded core with functionalized side chains protruding perpendicular to the helical axis to provide a highly predictable display of functional groups. This work paves the way for development of β-peptoid foldamers with a desired function, such as catalytic properties or as scaffolds enabling polyvalent display.
Wellh?fer, Isabelle,Frydenvang, Karla,Kotesova, Simona,Christiansen, Andreas M.,Laursen, Jonas S.,Olsen, Christian A.
p. 3762 - 3779
(2019/05/01)
NEW ANTIBACTERIAL COMPOUNDS
The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.
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Page/Page column 59-60
(2016/07/05)
5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
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Paragraph 0784
(2015/12/05)
Design and synthesis of novel sulfonamide-containing bradykinin hB 2 receptor antagonists. Synthesis and structure-relationships of α,α-tetrahydropyranylglycine
A series of α,α-cycloalkylglycine sulfonamide compounds of general formula 1 has previously been identified by our group as selective human B2(hB2) receptor antagonists. Here we report the in vitro and in vivo BK antagonist activity
Fincham, Christopher I.,Bressan, Alessandro,D'Andrea, Piero,Ettorre, Alessandro,Giuliani, Sandro,Mauro, Sandro,Meini, Stefania,Paris, Marielle,Quartara, Laura,Rossi, Cristina,Squarcia, Antonella,Valenti, Claudio,Daniela, Fattori,Maggi, Carlo Alberto
supporting information; experimental part
p. 2091 - 2100
(2012/05/05)
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