- Photochemistry of 2-(2-Furyl)-benzimidazole (Fuberidazole)
-
The photodegradation of 2-(2-furyl)-benzimidazole (Fuberidazole 1) has been reinvestigated employing advanced HPLC-UV/VIS techniques and fluorescence emission and excitation spectroscopy in methanol at natural pH, in acidic medium and in aqueous solutions at pH 7 and 3, and four main products benzimidazole-2-carboxyclic acid 3, its methyl ester 2, 1-methoxy benzimidazole 5, methyl 4-oxo-2-benzimidazole crotonate 7 (cis and trans isomers) besides benzimidazole 4 and 2,2'-bibenzimidazole 6 and other side products have been isolated and characterized.The kinetics of the photodegradation process was followed independently be HPLC-UV and fluorescence emission showing a significant similarity of the curve habit; this allows to monitor a photodegradation at very low concentrations (5*10-5 - 5*10-6 M).The quantum yield of disappearance of Fuberidazole has been determined. Key Words: 2-(2-Furyl)-benzimidazole, Fuberidazole, Photodegradation, HPLC Separation, Fluorescence Emission
- Herrmann, Christiane,Foerster, Rolf,Koch, Helmut,Wamhoff, Heinrich
-
p. 1431 - 1437
(2007/10/02)
-