- 1,2-diacetyl-4-phenyl-1,2,4-triazolidine-3,5-dione
-
The title crystal, C12H11N3O4, contains three essentially identical molecules in the asymmetric unit. The triazole rings in the three independent molecules are planar within 0.014 A. The N atom containing the ph
- Singh, Phirtu,Izydore, Robert A.
-
-
Read Online
- Hypolipidemic activity of 4-substituted 1,2-diacyl-1,2,4-triazolidine- 3,5-diones in rodents
-
A series of 4-substituted 1,2-diacyl-1,2,4-triazolidine-3,5-diones were synthesized and shown to be hypolipidemic in rodents; serum cholesterol and triglyceride levels were significantly reduced following intraperitoneal and oral dosing at 20 mg/kg/day. T
- Simlot,Izydore,Wong,Hall
-
-
Read Online
- Method for control of hyperlipidemia
-
The present invention is directed to a method of controlling hyperlipidemia in mammals which comprises administering to a mammal an amount effective to control hyperlipidemia of a compound having hypolipidemic activity and the structural formula: STR1 wherein R1 is hydrogen, a C1 to C18 alkyl or substituted alkyl, a C2 to C18 alkenyl or substituted alkenyl, a C2 to C18 alkynyl or substituted alkynyl, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, phenyl, a substituted phenyl, cyano, phenalkyl, --CO--R9 or --Y--CO--R9 ; R2 is STR2 R3 and R4 can be the same or different and are each the same as R1 ; R5, R6 and R7 can be the same or different and are each hydrogen, a C1 to C18 alkyl or substituted alkyl, a C2 to C18 alkenyl or substituted alkenyl, a C1 to C18 alkynyl or substituted alkynyl, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, phenyl or substituted phenyl, phenalkyl, --CO--R9, or --Y--CO--R9, with the proviso that R5 and R6 together cannot be so bulky as to cause the compound to decompose; R8 is hydrogen, a C1 to C5 alkyl, a C4 to C10 cycloalkyl, --CO--R9 or Y--CO--R9 ; R9 is hydrogen, a C1 to C5 alkyl or substituted alkyl, a C2 to C5 alkenyl or substituted alkenyl, a C2 to C5 alkynyl or substituted alkynyl, phenyl or substituted phenyl, phenoxy or substituted phenoxy, a C1 to C5 alkoxy or substituted alkoxy, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, --NHC6 C5l , --NR10 R11 wherein R10 and R11 can be the same or different and are each hydrogen, a C1 to C5 alkyl or substituted alkyl, phenyl or substituted phenyl; Y is a C1 to C10 alkylene or substituted alkylene; R12 is --CO, --COH, --CS, --CSH, or a C1 to C4 alkylene group; and and the pharmaceutically acceptable salts, and mixtures thereof.
- -
-
-