PhI(OAc)2and iodine-mediated synthesis ofN-alkyl sulfonamides derived from polycyclic aromatic hydrocarbon scaffolds and determination of their antibacterial and cytotoxic activities
The development of new approaches toward chemo- and regioselective functionalization of polycyclic aromatic hydrocarbon (PAH) scaffolds will provide opportunities for the synthesis of novel biologically active small molecules that exploit the high degree of lipophilicity imparted by the PAH unit. Herein, we report a new synthetic method for C-X bond substitution that is speculated to operateviaa N-centered radical (NCR) mechanism according to experimental observations. A series of PAH sulfonamides have been synthesized and their biological activity has been evaluated against Gram-negative and Gram-positive bacterial strains (using a BacTiter-Glo assay) along with a series of mammalian cell lines (using CellTiter-Blue and CellTiter-Glo assays). The viability assays have resulted in the discovery of a number of bactericidal compounds that exhibit potency similar to other well-known antibacterials such as kanamycin and tetracycline, along with the discovery of a luciferase inhibitor. Additionally, the physicochemical and drug-likeness properties of the compounds were determined experimentally and usingin silicoapproaches and the results are presented and discussed within.
Hopkins, Megan D.,Ozmer, Garett L.,Witt, Ryan C.,Brandeburg, Zachary C.,Rogers, David A.,Keating, Claire E.,Petcoff, Presley L.,Sheaff, Robert J.,Lamar, Angus A.
p. 1133 - 1144
(2021/02/16)
Blue fluorescent host compound, and preparation method and device thereof
The invention relates to a blue fluorescent host compound, and a preparation method and a device thereof. The structural formula of the blue fluorescent host compound is represented by chemical formula 1 shown in the description. Compared with a conventional material, the blue fluorescent host compound of the invention has the advantages of excellent electroluminescent properties, long device service life and proper color coordinates. The organic light-emitting device prepared from the blue fluorescent host compound adopts the novel compound of the chemical formula 1, so that the device becomes the organic light-emitting device with a high efficiency and a long service life. The preparation method of the blue fluorescent host compound has the advantages of simple process and high yield.
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Paragraph 0070-0074
(2020/01/12)
COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND A ELECTRONIC DEVICE THEREOF
The present invention refers to novel compounds, organic electroluminescence element and electronic device relates to using the same, according to the present invention emitting efficiency, color purity can be on the organic layer, can be facing ends of the lamps. (by machine translation)
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Paragraph 0141; 0145; 0147-0148
(2019/06/04)
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