668992-72-1

Water-stable anionic Ln2L2-type (Ln = LaIIIand EuIII) lanthanide-organic macrocycles have been constructed by deprotonation self-assembly of a bis-tridentate ligand consisting of two 2,6-bis-(1,2,4-triazole)-pyridine chelation arms bridged by a dibenzofuran chromophore, of which the luminescent Eu2L2macrocycle can be used for enantiomeric excess (ee) detection toward pybox-type chiral ligands and selective colorimetric sensing of omethoate (OMA) in water.

The invention discloses a C2 symmetric compound, which has a structure shown in the following formula I: wherein the range of an included angle between two single bonds of a group is 60-163 degrees; and the group comprises at least one of an arylene group or a heteroarylene group. The C2 symmetric compound provided by the invention can be used as an organic ligand to be assembled with lanthanide ions under the action of alkali to form a plurality of lanthanide organic polyhedral cages with novel structures, and the lanthanide organic polyhedral cages can stably exist in dimethyl sulfoxide and water and show excellent optical and magnetic resonance imaging behaviors.

Syntheses of very electron-rich dialkylamino-substituted 2,2':6',2''-terpyridines (TPYs) were adapted to moderate scale preparation without tedious purification of intermediates. The key 4'-bromo-6,6''-dimethyl-2,2':6',2''-terpyridine-4,4''-diyl bisnonaflate is now available in gram quantities. Its nucleophilic aromatic substitution with dimethylamine provided mixtures of 4'-bromo-substituted 4,4''-bis(dimethylamino)-TPY and the tris(dimethylamino)-TPY. The bromo compound was used in a Buchwald–Hartwig amination to provide the tris(dimethylamino)-TPY in excellent yield. The 4'-bromo substituent was reductively removed to furnish the bis(dimethylamino)-TPY. The same sequence of reactions with pyrrolidine as nucleophile leads to the hitherto unknown pyrrolidino-TPYs. Calculations at the MP2(FC)/6–31+G(2d,p)//B98/6-31G(d) level predict very high methyl cation affinities for compounds of this type, with the 4,4',4''-tri(pyrrolidin-1-yl)-TPY being the most Lewis basic TPY synthesized to date. The efficiently prepared electron-rich TPYs should be excellent ligands for many applications.

The application is directed to compounds of formula (IA) : and specifically compounds of formula (I) and their salts and solvates, wherein R1, R11, R12, R13, R4, R5, n, A1, A2, and A3 are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of conditions associated with the alteration of the activity of β-galactosidase, specially galactosidase beta-1 or GLB1, including GM1 gangliosidoses and Morquio syndrome, type B.

A versatile method for the synthesis of functionalized 2,2′:6′, 2″-terpyridines by assembly of the terminal pyridine rings is presented. The cyclization precursors - bis-β-ketoenamides - are prepared from 4-substituted 2,6-pyridinedicarboxylic acids and a

(Equation presented) A model system has been developed to study the synergy between aromatic stacking and hydrogen bonding in the binding of a flavin derivative. The results show that the identity of both the hydrogen bonding and π-stacking units strongly determine the overall receptor affinity for flavin in both the oxidized and radical anion forms.