Structure-activity relationships of novel potent MurF inhibitors
A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC 50=22~70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers.
Gu, Yu Gui,Florjancic, Alan S.,Clark, Richard F.,Zhang, Tianyuan,Cooper, Curt S.,Anderson, David D.,Lerner, Claude G.,McCall, J. Owen,Cai, Yingna,Black-Schaefer, Candace L.,Stamper, Geoffrey F.,Hajduk, Philip J.,Beutel, Bruce A.
p. 267 - 270
(2007/10/03)
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