- Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2Creceptor
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The syntheses, structure-activity relationships (SARs), and biological activities of tetrahydroquinoline-based tricyclic amines as 5-HT2Creceptor agonists are reported. An early lead containing a highly unique 6,6,7-ring system was optimized for both in vitro potency and selectivity at the related 5-HT2Breceptor. Orally bioactive, potent, and selective 6,6,6-tricyclic 5-HT2Cagonists were identified.
- Schrader, Thomas O.,Kasem, Michelle,Ren, Albert,Feichtinger, Konrad,Al Doori, Bilal,Wei, Jing,Wu, Chunrui,Dang, Huong,Le, Minh,Gatlin, Joel,Chase, Kelli,Dong, Jenny,Whelan, Kevin T.,Sage, Carleton,Grottick, Andrew J.,Semple, Graeme
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