cas 67973-32-4, 3,5-DIBROMO-4-METHYLBENZOIC ACID | Articles data ｜lookchem

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67973-32-4

Articles about 67973-32-4Total 1 be found

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Pyrazolopyrimidines as dual Akt/p70S6K inhibitors
Activation of the PI3K/Akt/mTOR kinase pathway is frequently associated with human cancer. Selective inhibition of p70S6Kinase, which is the last kinase in the PI3K pathway, is not sufficient for strong tumor growth inhibition and can lead to activation of upstream proteins including Akt through relief of a negative feedback loop. Targeting multiple sites in the PI3K pathway might be beneficial for optimal activity. In this manuscript we report the design of dual Akt/p70S6K inhibitors and the evaluation of the lead compound 11b in vivo, which was eventually advanced into clinical development.
Rice, Kenneth D.,Kim, Moon H.,Bussenius, Joerg,Anand, Neel K.,Blazey, Charles M.,Bowles, Owen J.,Canne-Bannen, Lynne,Chan, Diva S.-M.,Chen, Baili,Co, Erick W.,Costanzo, Simona,Defina, Steven C.,Dubenko, Larisa,Engst, Stefan,Franzini, Maurizio,Huang, Ping,Jammalamadaka, Vasu,Khoury, Richard G.,Klein, Rhett R.,Laird, A.Douglas,Le, Donna T.,Mac, Morrison B.,Matthews, David J.,Markby, David,Miller, Nicole,Nuss, John M.,Parks, Jason J.,Tsang, Tsze H.,Tsuhako, Amy L.,Wang, Yong,Xu, Wei
supporting information; scheme or table
p. 2693 - 2697
(2012/05/20)

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Chemical Properties

Melting Point: 242 ºC
Boiling Point: 374.6 °C at 760 mmHg
Flash Point:180.3 °C
Density: 1.951 g/cm³
Storage Temp.:Sealed in dry,Room Temperature
Vapor Pressure: 2.82E-06mmHg at 25°C
Refractive Index: 1.627
PKA: 3.59±0.10(Predicted)
BRN: 2577656
PSA: 37.30000
LogP: 3.21820

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