cas 6802-78-4, 7,7-Dibromo-bicyclo[4.1.0]hept-3-ene

Articles about 6802-78-4Total 11 be found

TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS
Disclosed are a series of compounds or their tautomers having a general structure represented by Formula (la), (lb), (Ila), (lIb), or (lIc) and pharmaceutically acceptable salts thereof. The present disclosure also relates to pharmaceutical compositions comprising said compounds or tautomers. The present disclosure further relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis comprising administering to a subject in need thereof a therapeutically effective amount of Formula (la), (lb), (Ila), (lIb), or (lIc) compounds or tautomers.
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Page/Page column 56

(2021/04/23)

HINOKITIOL ANALOGUES, METHODS OF PREPARING AND PHARMACEUTICAL COMPOSITIONS THEREOF
Disclosed are analogues of hinokitiol, methods for preparing them, and pharmaceutical compositions thereof. Also disclosed are methods for their use in treating iron-related diseases.
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Page/Page column 213

(2019/11/04)

Abnormal Nucleophilic Substitution on Methoxytropone Derivatives: Steric Strategy to Synthesize 5-Substituted Azulenes
Azulene is a non-alternant non-benzenoid aromatic system, and in turn, it possesses unusual photophysical properties. Azulene-based conjugated systems have received increasing interest in recent years as optoelectronic materials. Despite the routes availa
Kumar, Neha Rani,Agrawal, Abhijeet R.,Zade, Sanjio S.
supporting information
p. 14064 - 14071
(2019/11/03)

The metal complex, a chiral nematic liquid crystal composition and crystal (by machine translation)
[Problem] helical twisting power (βM ) Is increased, and, compatibility with a large metal complex of a nematic liquid crystal, chiral nematic liquid crystal composition using the same, and a liquid crystal element. (1) Or formula (2) represented by the formula [a] complex. (1) Or formula (2) in the metal complex represented by formula having chirality, nematic liquid crystal compounds containing chiral nematic liquid crystal compositions. Chiral nematic liquid crystal composition is filled between a pair of liquid crystal element. (R is C1 a-20 straight chain alkyl group or an alkoxy group of straight chain C1 a-20)[Drawing] no (by machine translation)
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Paragraph 0048; 0049

(2019/03/01)

Tropolone-terminated oligomeric fluorophores with responsive properties to external environment
Tropolone-terminated oligomeric fluorophores (Tp20P, Tp20PV, and Tp20PE) were prepared by palladium-catalyzed coupling reactions. A phenylene-type Tp20P showed an emission maximum in the blue fluorescent region and the fluorescence quantum yield was relat
Takagi, Koji,Saiki, Kazuhiro,Hayashi, Hirokazu,Ohsawa, Hiroyasu,Matsuoka, Shin-Ichi,Suzuki, Masato
supporting information; experimental part
p. 236 - 241
(2009/05/30)

Efforts directed toward the synthesis of colchicine: Application of palladium-catalyzed siloxane cross-coupling methodology
Colchicine is an important and synthetically challenging natural product. The key synthetic step in this approach to the synthesis of colchicine involved a palladium-catalyzed cross-coupling reaction between 5-bromotropolone (4) and an aryl siloxane to form the aryl-tropolone bond. The coupling of a variety of highly functionalized aryl siloxane derivatives was investigated and optimized coupling conditions were developed. It was discovered that a palladium catalyst with a high degree of phosphine ligand coordination (5 equiv of phosphine/mol Pd) was necessary to efficiently couple aryl siloxanes with 5-bromotropolone (4). In addition, the coupling approach has provided a direct comparison between siloxane and boronic acid coupling technologies that demonstrated that aryl siloxanes and boronic acids produce similar yields of highly functionalized biaryl products.
Seganish, W. Michael,Handy, Christopher J.,DeShong, Philip
p. 8948 - 8955
(2007/10/03)

Practical synthesis of biaryl colchicinoids containing 3′,4′- catechol ether-based A-rings via Suzuki cross-coupling with ligandless palladium in water
Eight new biaryl colchicinoids containing 3′,4′-methylene or benzodioxy ether bridges were synthesized. The key synthetic step employed a ligandless, aqueous Suzuki cross-coupling reaction catalyzed by Pd(OAc) 2 with tetrabutylammonium bromide (TBAB) and potassium carbonate (K2CO3). The biaryl Suzuki products were typically formed in 5-30min and always in less than 1h.
Deveau, Amy Morin,Macdonald, Timothy L.
p. 803 - 807
(2007/10/03)

Exploring a new general pathway to parent hydrocarbons heptafulvene, heptapentafulvalene, and heptafulvalene
A new general pathway to the parent cross-conjugated hydrocarbons heptafulvene (1) (Scheme 3), sesquifulvalene (2) (Scheme 4), and heptafulvalene (3) (Scheme 5) has been explored, starting with easily available 7,7-dibromobicyclo[4.1.0]hept-3-ene (13). Promising precursors have been synthesized by halo/lithio exchange of 1,1-dibromocyclopropane 13 → 14, followed by methylation (→1), cyclopentadienylation (→2) and CuCl2-induced 'carbene dimerization' (→3) of the carbenoid 14. So far, the main obstacle of all three sequences (cf. Schemes 3, 4, and 5) is the final base-induced dehydrobromination of precursors 17, 24, and 27, which should be investigated in more detail.
Li, Xiaoming,Neuenschwander, Markus
p. 562 - 570
(2007/10/03)

A Convenient Preparation of 7,7-Dimethyl-1,3,5-cycloheptatriene
Described is a four-step synthesis of 7,7-dimethyl-1,3,5-cycloheptatriene, which starts from readily available 1,4-cyclohexadiene.Monocyclopropanation of this compound with dibromocarbene followed by replacement of the halogens with methyl groups using a higher order cuprate reagent provides the corresponding norcarene which is subjected to a bromination-dehydrobromination sequence to give the title compound.
Rigby, James H.,Bellemin, Anne-Roberte
p. 188 - 189
(2007/10/02)

Attempted Synthesis of Some α-Halolactones Fused in Bicycloheptanes
For the synthesis of the lactones A, B and C, compounds 4a, 4b, 10a and 10b were synthesized by dihalocyclopropanation and epoxidation of the dienes 1 and 7. 4a and 10a on hydrolysis give the corresponding diols 11 and 12.Treatment of 10a and 10b with BuLi/CO2 at -90 deg C gives the α-halocarboxylic acids 13a and 13b respectively.Both 13a and 13b on hydrolysis with 2N H2SO4 in acetone afford polymeric material, from which no pure product could be isolated.A dihydroxy-α-chlorocyclopropyl ester (17) has been synthesized from 1 but no lactone could be isolated.
Hashem, Md. Abul
p. 424 - 429
(2007/10/02)

Synthesis of Polycyclic Homocyclopropylcarbinols by Reductive Cyclization of Bromocyclopropyl Epoxides
A new synthetic route to polycyclic homocyclopropylcarbinols has been realized by lithiation of bromocyclopropyl epoxides with n-butyllithium and subsequent intramolecular attack of the metalated cyclopropane ring onto the epoxide.A series of seven bromoc
Last, Larry A.,Fretz, E. Robert,Coates, Robert M.
p. 3211 - 3219
(2007/10/02)