- Au(I)-Catalyzed 6-endo-dig Cyclizations of Aromatic 1,5-Enynes to 2-(Naphthalen-2-yl)anilines Leading to Divergent Syntheses of Benzo[α]carbazole, Benzo[c,h]cinnoline and Dibenzo[i]phenanthridine Derivatives
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A gold(I)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines. The functional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed. The derivatization of 2-(naphthalen-2-yl)aniline was carried out to facile access to benzo[α]carbazole, benzo[c,h]cinnoline and dibenzo[i]phenanthridine derivatives in a divergent way.
- Fu, Jiayue,Li, Bingbing,Wang, Xiugui,Liang, Qida,Peng, Xiaoshi,Yang, Lu,Wan, Tao,Wang, Xinxiu,Lin, Bin,Cheng, Maosheng,Liu, Yongxiang
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supporting information
p. 46 - 52
(2021/11/20)
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- Catalytic Cyclotrimerization Pathway for Synthesis of Selaginpulvilins C and D: Scope and Limitations
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A facile and unified approach to the main selaginpulvilin's framework was achieved by catalytic [2 + 2 + 2]-cyclotrimerization of a triyne with monosubtituted alkynes. The reaction proceeded with high "ortho"selectivity by using Wilkinson's catalyst (RhCl
- Rycek, Lukas,Mateus, Miguel,Beytlerová, Nela,Kotora, Martin
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p. 4511 - 4515
(2021/04/12)
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- Synthesis of phthalan derivatives via a formal intramolecular 1,3-insertion of rhodium(II) azavinyl carbenes into O[sbnd]Si bond
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The first formal intramolecular 1,3-insertion into O[sbnd]Si bond of rhodium(II) azavinyl carbene have been developed, and valuable phthalan derivatives could be synthesized efficiently. In addition, various functional groups could be introduced to the pr
- Deng, Changchang,Duan, Shengguo,Jie, Yuchen,Luo, Huan,Xiang, Qiaoyi,Xu, Ze-Feng
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supporting information
(2021/08/30)
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- Photocatalytic Decarboxylative [3 + 2] and [4 + 2] Annulation of Enynals and γ,σ-Unsaturated N-(Acyloxy)phthalimides by NaI/PPh3Catalysis
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A practical and eco-friendly strategy for the radical-mediated decarboxylative [3 + 2] and [4 + 2] annulation of enynals and γ,σ-unsaturated N-(acyloxy)phthalimides through the photoactivation of an electron donor-acceptor (EDA) complex has been developed. A wide range of primary, secondary, and tertiary alkyl N-hydroxyphthalimide (NHP) esters can be used as suitable substrates for the synthesis of fused ketones without any transition-metal catalysts or oxidants. This protocol features a broad substrate scope, excellent selectivity, and clean reaction conditions.
- Liu, Xiao-Jie,Zhou, Sheng-Yun,Xiao, Yuting,Sun, Qing,Lu, Xin,Li, Yang,Li, Jin-Heng
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supporting information
p. 7839 - 7844
(2021/10/20)
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- A Gold(I)-Catalyzed Tandem Cyclization to Benzo[b]indeno[1,2-e][1,4]diazepines from o-Phenylenediamines and Ynones
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A gold-catalyzed tandem cyclization of o-phenylenediamines with ynones to synthesize benzo[b]indeno[1,2-e][1,4]diazepine has been developed. The mechanism was explored by control experiments. The method provides a way to access a range of benzo[b]indeno[1,2-e][1,4]diazepine derivatives in diversity-oriented synthesis aiming at discovering structurally diverse scaffolds. (Figure presented.).
- Xie, Fukai,Zhang, Bo,Chen, Yanyu,Jia, Hongwei,Sun, Lei,Zhuang, Kaitong,Yin, Lili,Cheng, Maosheng,Lin, Bin,Liu, Yongxiang
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supporting information
p. 3886 - 3897
(2020/08/06)
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- Palladium-catalyzed chemoselective aminomethylative cyclization and aromatizing allylic amination: Access to functionalized naphthalenes
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A palladium-catalyzed chemoselective aminomethylative cyclization and aromatizing allylic amination of enyne-tethered allylic alcohols with aminals is described. Under the reaction conditions, the cationic vinyl allylpalladium species undergoes selective migratory insertion of alkenes rather than reductive elimination with nucleophiles. This strategy provides an efficient and unique approach to the construction of functionalized naphthalenes, which are important building blocks in synthetic organic chemistry. Mechanistic studies have revealed that the selective sequential migratory insertion of enyne and alkene is crucial for the cyclization.
- Yu, Bangkui,Yu, Houjian,Huang, Hanmin
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p. 8962 - 8966
(2020/11/13)
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- Generation of Donor/Donor Copper Carbenes through Copper-Catalyzed Diyne Cyclization: Enantioselective and Divergent Synthesis of Chiral Polycyclic Pyrroles
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The generation of metal carbenes from readily available alkynes represents a significant advance in metal carbene chemistry. However, most of these transformations are based on the use of noble-metal catalysts and successful examples of such an asymmetric version are still very scarce. Here a copper-catalyzed enantioselective cascade cyclization of N-propargyl ynamides is reported, enabling the practical and atom-economical construction of diverse chiral polycyclic pyrroles in generally good to excellent yields with wide substrate scope and excellent enantioselectivities (up to 97:3 e.r.). Importantly, this protocol represents the first copper-catalyzed asymmetric diyne cyclization. Moreover, mechanistic studies revealed that the generation of donor/donor copper carbenes is presumably involved in this 1,5-diyne cyclization, which is distinctively different from the related gold catalysis, and thus it constitutes a novel way for the generation of donor/donor metal carbenes.
- Hong, Feng-Lin,Wang, Ze-Shu,Wei, Dong-Dong,Zhai, Tong-Yi,Deng, Guo-Cheng,Lu, Xin,Liu, Rai-Shung,Ye, Long-Wu
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supporting information
p. 16961 - 16970
(2019/10/16)
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- Synthesis of Fluorescent Azafluorenones and Derivatives via a Ruthenium-Catalyzed [2 + 2 + 2] Cycloaddition
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An original and mild synthetic route for the preparation of novel azafluorenones and derivatives via a ruthenium-mediated [2 + 2 + 2] cycloaddition of α,ω-diynes and cyanamides has been developed. This atom-economical catalytic process demonstrated remarkable regioselectivities to access fluorescent azafluorenone derivatives. The photophysical properties of azafluorenone derivatives have been evaluated, and photoluminescence phenomena at solid and liquid states have been highlighted.
- Ye, Fei,Tran, Christine,Jullien, Ludovic,Le Saux, Thomas,Haddad, Mansour,Michelet, Véronique,Ratovelomanana-Vidal, Virginie
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supporting information
p. 4950 - 4953
(2018/08/24)
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- Syntheses of 12H-benzo[a]xanthen-12-ones and benzo[a]acridin-12(7H)-ones through Au(i)-catalyzed Michael addition/6-endo-trig cyclization/aromatization cascade annulation
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A multifaceted gold(i)-catalyzed aromaticity-driven double 6-endo cascade cyclization strategy to synthesize both 12H-benzo[a]xanthen-12-ones and benzo[a]acridin-12(7H)-ones, whose core motifs xanthone and acridone both exist as important scaffolds in an
- Xiong, Zhiling,Zhang, Xinhang,Li, Yangming,Peng, Xiaoshi,Fu, Jiayue,Guo, Jiajia,Xie, Fukai,Jiang, Chongguo,Lin, Bin,Liu, Yongxiang,Cheng, Maosheng
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p. 7361 - 7374
(2018/10/24)
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- De Novo Synthesis of Phenols and Naphthols through Oxidative Cycloaromatization of Dienynes
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In this work, a rhodium-catalyzed oxidative cycloaromatization of dienynes, which provides a highly straightforward and efficient way to access polysubstituted naphthols and phenols under mild conditions, is described. Challenged electron-withdrawing groups are well tolerated in this protocol, and late-stage phenyl ring formation is demonstrated.
- Rong, Ming-Guang,Qin, Tian-Zhu,Liu, Xin-Rui,Wang, Hong-Fa,Zi, Weiwei
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supporting information
p. 6289 - 6293
(2018/10/09)
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- Dual Gold-Catalyzed Three-Component Reaction: Efficient Synthesis of Indene-Fused Esters, Acids, and Lactones through Gold Vinylidene Intermediates
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A dual gold(I)-catalyzed three-component reaction was developed to prepare indene-fused carboxylic acid derivatives from diynes, alcohols, and pyridine N-oxides in both inter- and intramolecular fashions. The pyridine N-oxides were found to exhibit distinct selectivity unlike the α-oxo gold carbene intermediates in the well-developed gold-catalyzed oxidative functionalization of alkynes. Experimental studies and DFT calculations support double nucleophilic substitution of a gold vinylidene intermediate.
- Yu, Congjun,Ma, Xiaodong,Chen, Bin,Tang, Bencan,Paton, Robert S.,Zhang, Guozhu
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supporting information
p. 1561 - 1565
(2017/04/01)
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- Lewis Acid-Catalyzed Intramolecular [3+2] Cross-Cycloaddition of Aziridine 2,2-Diesters with Conjugated Dienes for Construction of Aza-[n.2.1] Skeletons
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A novel Lewis acid-catalyzed [3+2] intramolecular cross-cycloaddition (IMCC) between aziridine 2,2-diesters and conjugated dienes has been developed. This is the first regiospecific IMCC of intramolecular 1,3-dipolar cycloadditions of azomethine ylides with carbon=carbon double bonds, and supplies a general and efficient strategy for construction of structurally complex and diverse aza-[n.2.1] skeletons. The [3+2]IMCC could be carried out under mild conditions and in gram scale. More importantly, 3-alkyl-substituted aziridines were also successful. The excellent structural diversity, the facile operation and the versatile post-modifications will support the applications of the [3+2]IMCC in natural products synthesis and drugs discovery.
- Zhan, Yizhou,Liu, Tao,Ren, Jun,Wang, Zhongwen
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supporting information
p. 17862 - 17866
(2017/11/27)
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- Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis
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A stereoselective one-pot synthesis of spiropyrazolones through an organocatalytic asymmetric Michael addition and a formal Conia-ene reaction has been developed. Depending on the nitroalkene, the 5-exo-dig-cyclization could be achieved by silver-catalyzed alkyne activation or by oxidation of the intermediate enolate. The mechanistic pathways have been investigated using computational chemistry and mechanistic experiments.
- Hack, Daniel,Dürr, Alexander B.,Deckers, Kristina,Chauhan, Pankaj,Seling, Nico,Rübenach, Lukas,Mertens, Lucas,Raabe, Gerhard,Schoenebeck, Franziska,Enders, Dieter
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supporting information
p. 1797 - 1800
(2016/02/03)
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- Total Synthesis of Selaginpulvilin C and D Relying on in Situ Formation of Arynes and Their Hydrogenation
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The total syntheses of selaginpulvilins C and D is described. The key strategy for the construction of the core fluorene moiety involves in situ formation of an aryne intermediate followed by its formal hydrogenation. The precursor tetraynes that undergo
- Karmakar, Rajdip,Lee, Daesung
-
supporting information
p. 6105 - 6107
(2016/12/09)
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- Rhodium(II)-Catalyzed and Thermally Induced Intramolecular Migration of N-Sulfonyl-1,2,3-triazoles: New Approaches to 1,2-Dihydroisoquinolines and 1-Indanones
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New rhodium(II)-catalyzed or thermally induced intramolecular alkoxy group migration of N-sulfonyl-1,2,3-triazoles has been developed, affording divergent synthesis of 1,2-dihydroisoquinoline and 1-indanone derivatives according to different conditions. N-Sulfonyl keteneimine is the key intermediate for the synthesis of dihydroisoquinoline, whereas the aza-vinyl carbene intermediate results in the formation of 1-indanone.
- Sun, Run,Jiang, Yu,Tang, Xiang-Ying,Shi, Min
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supporting information
p. 5727 - 5733
(2016/04/20)
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- A Au(i)-catalyzed hydrogen bond-directed tandem strategy to synthesize indeno-chromen-4-one and indeno-quinolin-4-one derivatives
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A gold-catalyzed hydrogen bond-directed tandem cyclization strategy to synthesize indeno-chromen-4-one and indeno-quinolin-4-one derivatives has been developed. The hydrogen bond existing between the hydroxyl group (or the amide group) and the carbonyl group played an essential role in controlling the selectivity, which was confirmed by both experimental and theoretical evidence.
- Jiang, Chongguo,Xiong, Zhiling,Jin, Shengfei,Gao, Peng,Tang, Yingzhan,Wang, Yanshi,Du, Chuan,Wang, Xiaoyu,Liu, Yang,Lin, Bin,Liu, Yongxiang,Cheng, Maosheng
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supporting information
p. 11516 - 11519
(2016/10/03)
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- Gold-catalyzed Intermolecular Oxidations of 2-Ketonyl-1-ethynyl Benzenes with N-Hydoxyanilines to Yield 2-Aminoindenones via Gold Carbene Intermediates
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Gold-catalyzed oxidations of 2-ketonyl-1-ethynyl benzenes with N-hydroxyanilines yield 2-aminoindenone derivatives efficiently. Experimental data suggests that this process involves an α-oxo gold carbene intermediate, generated from the attack of N-hydroxyaniline on furylgold carbene intermediate, rather than the typical attack of oxidants on π-alkynes.
- Mokar, Bhanudas Dattatray,Huple, Deepak B.,Liu, Rai-Shung
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supporting information
p. 11892 - 11896
(2016/11/16)
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- Stereoselective Synthesis of Oxabicyclo[2.2.1]heptenes via a Tandem Dirhodium(II)-Catalyzed Triazole Denitrogenation and [3 + 2] Cycloaddition
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A novel synthetic strategy for the diastereoselective synthesis of structurally diverse oxabicyclo[2.2.1]heptenes has been developed, featuring a tandem reaction combining a Rh-catalyzed triazole denitrogenation and a novel type of [3 + 2] cycloaddition reaction. This tandem reaction was thought to proceed via a five-membered oxonium ylide intermediate, which was formed by the intramolecular nucleophilic attack of the carbonyl group on the α-imino metallocarbene followed by an inter- or intramolecular [3 + 2] dipolar cycloaddition with a range of alkynes and alkenes.
- Yuan, Hao,Gong, Jianxian,Yang, Zhen
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supporting information
p. 5500 - 5503
(2016/11/17)
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- Enantioselective synthesis of 1,2-dihydronaphthalene-1-carbaldehydes by addition of boronates to isochromene acetals catalyzed by tartaric acid
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Tartaric acid is an ideal asymmetric catalyst as it is abundant, cheap, and environmentally friendly. (+)-Tartaric acid was found to catalyze a novel enantioselective [4 + 2] cycloaddition of isochromene acetals and vinylboronates. A variety of substituted isochromene acetals were tolerated, furnishing the desired dihydronaphthalenes and dihydrobenzofluorene products in good yields. High enantiomeric ratios (up to 98.5:1.5) and excellent diastereoselectivities (all >99:1) were observed employing 10 mol % of (+)-tartaric acid as the catalyst, in combination with 5 mol % of Ho(OTf)3.
- Luan, Yi,Barbato, Keith S.,Moquist, Philip N.,Kodama, Tomohiro,Schaus, Scott E.
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supporting information
p. 3233 - 3236
(2015/03/30)
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- Pd(II)-Catalyzed Cycloisomerization/Dipolar Cycloaddition Cascade of N-Arylnitrone Alkynes with Olefins
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A cycloisomerization/dipolar cycloaddition tandem reaction of nitrone alkynes and electron-deficient olefins was described by employing a simple palladium catalyst. N-Arylnitrone alkynes, which were not well tolerated in previously reported methodologies, were successfully incorporated in the tandem reaction with generally good yields and moderate diastereoselectivities.
- Du, Yu-Liu,Zhu, Yi-Fan,Han, Zhi-Yong
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p. 7732 - 7738
(2015/08/18)
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- Enantioselective allylation of selected ortho-substituted benzaldehydes: A comparative study
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We report a systematic study of the allylation of ortho-substituted benzaldehydes under catalysis of a Lewis base (N, Ndioxide), a Lewis acid (Keck allylation), and a Bronsted acid. ortho-Halobenzaldehydes were used as the aldehydic substrates, and specia
- Hessler, Filip,Betk, Robert,Kadlkov, Aneta,Belle, Roman,Kotora, Martin
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p. 7245 - 7252
(2015/01/09)
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- Dihydrobiphenylenes through ruthenium-catalyzed [2+2+2] cycloadditions of ortho-alkenylarylacetylenes with alkynes
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A new synthetic route to dihydrobiphenylenes has been developed. The process involves a mild RuII-catalyzed [2+2+2] dimerization of ortho-alkenylarylacetylenes or its more versatile variant, the Ru-catalyzed [2+2+2] cycloaddition of ortho-ethynylstyrenes with alkynes. Mechanistic aspects of this [2+2+2] cycloaddition are discussed. A new synthetic route to dihydrobiphenylenes involves a mild RuII-catalyzed [2+2+2] dimerization of ortho-alkenylarylacetylenes or its more versatile variant, the Ru-catalyzed [2+2+2] cycloaddition of ortho-ethynylstyrenes with alkynes. The mechanistic aspects of this [2+2+2] cycloaddition are also discussed. Copyright
- Garcia-Rubin, Silvia,Gonzalez-Rodriguez, Carlos,Garcia-Yebra, Cristina,Varela, Jesus A.,Esteruelas, Miguel A.,Saa, Carlos
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supporting information
p. 1841 - 1844
(2014/03/21)
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- Gold-catalyzed carboalkoxylations of 2-ethynylbenzyl ethers to form 1- and 2-indanones chemoselectively: Effects of ligands and solvents
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The selective syntheses of 1- and 2-indan-one compounds from 2-ethynylbenzyl ethers have been achieved with suitable catalysts and solvents. The highly acidic [tris(pentafluorophenyl)phos-phine]gold hexafluoroantimonate [(C6F5)3AuSbF6] in nitromethane (MeNO2) preferably gives 1-indan-ones whereas [(ortho-biphenyl) di(tert-butyl)phosphine] gold triflimide [(tBu)2(o-biphenyl) AuNTf2] in dichloroethane tends to form 2-indanone derivatives. For 2-indanone products, we isolated two indenyl methyl ethers for deuterium labeling analyses, providing evidence for p-alkyne activation.
- Wang, Chiou-Dong,Hsieh, Yi-Feng,Liu, Rai-Shung
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supporting information
p. 144 - 152
(2014/03/21)
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- Au(i)-catalyzed triple bond alkoxylation/dienolether aromaticity-driven cascade cyclization to naphthalenes
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A novel strategy for the synthesis of multisubstituted naphthalenes was developed via a Au(i)-catalyzed alkyne alkoxylation/dienolether aromaticity-driven cascade cyclization using 1,5-enyne substrates. The functional group toleration was examined by synthesizing a series of substrates and the mechanism was also studied based on intermediates isolated through deuterium labeling experiments. This journal is the Partner Organisations 2014.
- Liu, Yongxiang,Guo, Jia,Liu, Yang,Wang, Xiaoyu,Wang, Yanshi,Jia, Xinyu,Wei, Gaofei,Chen, Lizhu,Xiao, Jianyong,Cheng, Maosheng
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supporting information
p. 6243 - 6245
(2014/06/09)
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- Enantioselective construction of [6,5,6]-carbocyclic systems by organo/metal-catalyzed sequential reactions
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An efficient strategy for the enantioselective construction of [6,5,6]-carbocyclic compounds has been established via one-pot reaction of (E)-4-(2-ethynylphenyl)but-3-en-2-ones with maleimide sequentially catalyzed by cinchona alkaloid-based primary amine and gold complex (Ph 3PAuNTf2). This methodology provided a facile approach to access the [6,5,6]-tricyclic skeleton in fairly good yield and with perfect enantioselectivities (98% to >99% ee).
- Wu, Xiang,Li, Ming-Li,Chen, Dian-Feng,Chen, Shu-Sen
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p. 4743 - 4750
(2014/06/09)
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- Gold-catalyzed cyclization/oxidative [3+2] cycloadditions of 1,5-enynes with nitrosobenzenes without additional oxidants
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Golden control: The title reaction (see scheme) proceeds with high stereocontrol to generate the heterocyclic products in good yield. Experiments to probe the mechanism were performed. Copyright
- Chen, Chun-Hao,Tsai, Yen-Ching,Liu, Rai-Shung
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supporting information
p. 4599 - 4603
(2013/05/21)
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- Gold(I)-catalyzed enantioselective carboalkoxylation of alkynes
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A highly enantioselective carboalkoxylation of alkynes catalyzed by cationic (DTBM-MeO-Biphep)gold(I) complexes is reported. Various optically active β-alkoxyindanone derivatives were obtained in good yields with high enantioselectivities. Furthermore, this methodology was extended to the enantioselective synthesis of 3-methoxycyclopentenones. The reaction is proposed to proceed through an enantioselective cyclization of intermediates containing vinylgold(I) and prochiral oxocarbenium moieties.
- Zi, Weiwei,Toste, F. Dean
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supporting information
p. 12600 - 12603
(2013/09/23)
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- One-pot synthesis of aromatic fused 2,3-dihydroindanone by tandem Pauson-Khand/Michael/Henry reaction
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The intermolecular Pauson-Khand reaction between 2-ethynylbenzaldehyde and ethylene promoted by dimethyl sulfide can be utilized to synthesize 2-(2-formylphenyl)cyclopentenone efficiently. This compound and its derivatives undergo a cascade process of Michael addition reaction followed by Henry reaction with nitromethane to construct substituted aromatic fused 2,3-dihydroindanones. Furthermore, direct one-pot synthesis of aromatic fused 2,3-dihydroindanones from 2-ethynylbenzaldehyde is achieved. Copyright
- Li, Mingming,Xing, Ping,Huang, Zuogang,Jiang, Biao
-
-
- NHC-catalyzed oxidative cyclization reactions of 2-alkynylbenzaldehydes under aerobic conditions: Synthesis of O-Heterocycles
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Chemical equations presented. An NHC-catalyzed, regio- and stereoselective oxidative cyclization of o-alkynylbenzaldehydes bearing an unactivated alkyne moiety as an internal electrophile has been developed to afford phthalides and isocoumarins. A single organocatalytic system enabled two sequential C-O bond formations to take place in an atom economical manner via highly efficient dual activation. Molecular oxygen in air could be utilized as a source of an oxygen atom for the oxidation of aldehydes to the corresponding benzoic acids under our newly developed reagent system.
- Park, Jong Hyub,Bhilare, Sachin V.,Youn, So Won
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supporting information; experimental part
p. 2228 - 2231
(2011/07/09)
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- Efficient syntheses of α-pyridones and 3(2H)-isoquinolones through ruthenium-catalyzed cycloisomerization of 3-en-5-ynyl and o-alkynylphenyl nitrones
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We report a new catalytic synthesis of α-pyridones and 3(2H)-isoquinolones from readily available 3-en-5-ynyl nitrones and o-alkynylphenyl nitrones; the reaction mechanism is proposed to involve iminyl ketene species through an oxygen transfer process.
- Pati, Kamalkishore,Liu, Rai-Shung
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supporting information; experimental part
p. 5233 - 5235
(2010/01/31)
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- An unusual access to medium sized cycloalkynes by a new goId(I)-catalysed cycloisomerisation of diynes
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A study was conducted to demonstrate efficient cycloisomerization of a series of 1,9- and 1,10-diynes into medium sized cycloalkynes by a gold-catalyzed alkyne-alkyne coupling. The reaction was performed using 4 mol% of gold complex in CD2Cl2 at room temperature and was monitored by using 1H NMR spectroscopy. The reaction of analogous diyne substrate was more rapid and a complete conversion was observed after 40 hours at room temperature. The cycloalkyne was isolated as a solid in 95% yield from which single crystals suitable for X-ray crystal structure determination was obtained. A rapid screening of catalysts and experimental conditions was undertaken to optimize the formation of cycloalkyne. A mechanistic proposal was also introduced for the cycloisomerization of diynes into cycloalkynes on the basis of the experimental observations.
- Odabachian, Yann,Le Goff, Xavier F.,Gagosz, Fabien
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supporting information; scheme or table
p. 8966 - 8970
(2010/04/25)
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- Construction of quaternary centres for natural polycycles: The Pauson-Khand approach
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Construction of quaternary carbons is a challenge in PK chemistry, with few precedents in the literature. Starting from suitable functionalized enynes including an aromatic ring that templates the reaction, polycyclic ketones are obtained with a quaternar
- Arnáiz, Eduardo,Blanco-Urgoiti, Jaime,Abdi, Delbrin,Domínguez, Gema,Castells, Javier Pérez
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p. 2431 - 2437
(2008/09/20)
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- Synthesis, structure, and reactivity of naphthalyne-Co2(CO) 6 complexes
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Synthesis of naphthalyne-Co2(CO)6 complexes, the first example of the aryne-Co2(CO)6 complex, was achieved via cyclization of acyclic alkyne-Co2(CO)6 complex precursors containing an allyls
- Iwasawa, Nobuharu,Otsuka, Maiko,Yamashita, Satomi,Aoki, Masao,Takaya, Jun
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p. 6328 - 6329
(2008/12/22)
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- Tandem Enyne Metathesis-Diels-Alder Reaction for Construction of Natural Product Frameworks
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Enynes connected through aromatic rings are used as substrates for metathesis reactions. The reactivity of three ruthenium carbene complexes is compared. The resulting 1,3-dienes are suitable precursors of polycyclic structures via a Diels-Alder process.
- Rosillo, Marta,Dominguez, Gema,Casarrubios, Luis,Amador, Ulises,Perez-Castells, Javier
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p. 2084 - 2093
(2007/10/03)
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