PYRROLO[3,2-B]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
The present invention provides novel pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.
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Page/Page column 54
(2010/10/20)
Synthesis of New Substituted Quinolizidines as Potential Inhibitors of Ergosterol Biosynthesis.
Carbocationic species (High Energy Intermediates) have been postulated as intermediates in the course of enzymatic synthesis of ergosterol.Protonated aza-analogues of the sterol are thus potential inhibitors.The synthesis of substituted quinolizidines (3) is reported. 4-Methoxy-2,3-dimethylpyridine (4) was metalated and reacted with substituted 3-chloropropanal to build the 1-methyl-2-quinolizidinone.The lateral chain was prepared via a Wittig-Horner reaction.
Godard, Alain,Lamour, Philippe,Ribereau, Pierre,Queguiner, Guy
p. 3247 - 3264
(2007/10/02)
Synthetic studies of the antitumor antibiotic streptonigrin. 3. Synthesis of the C-D ring of streptonigrin by an unsymmetrical Ullmann reaction
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Wittek,Liao,Cheng
p. 870 - 872
(2007/10/08)
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