cas 68827-43-0, Benzenecarboximidamide, 3,4-diamino- | Articles data ｜lookchem

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68827-43-0

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Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents
A new class of novel bis-benzimidazole diamidine compounds have been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Anti-MRSA and anti-VRE activities of the most potent compound 1 were more act
Hu, Laixing,Kully, Maureen L.,Boykin, David W.,Abood, Norman
scheme or table
p. 1292 - 1295
(2009/10/15)

Sulfonamide bridging compounds that inhibit tryptase activity
The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds and methods for treating or preventing an inflammatory disease.
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(2008/06/13)

Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles)
A series of bis(amidinobenzimidazoles) and bis(amidinoindoles) with varied linking chains connecting the aromatic groups and various modifications to the basic amidino groups have been prepared. The calf thymus (CT) DNA and nucleic acid homopolymer [poly(dA)·poly(dT), poly(dA-dT)·poly-(dA-dT), and poly(dG-dC)·poly(dG-dC)] binding properties of these compounds have been studied by thermal denaturation (ΔT(m)) and viscosity. The compounds show a greater affinity for poly(dA)·poly(dT) and poly(dA-dT)·poly(dA-dT) than for poly(dG-dC)·poly(dG-dC). Viscometric titrations indicate that the compounds do not bind by intercalation. Molecular modeling studies and the biophysical data suggest that the molecules bind to the minor groove of CT DNA and homopolymers. Analysis of the shape of the molecules is consistent with this mode of nucleic acid binding. Compounds with an even number of methylenes connecting the benzimidazole rings have a higher affinity for DNA than those with an odd number of methylenes. Molecular modeling calculations that determine the radius of curvature of four defined groups in the molecule show that the shape of the molecule, as a function of chain length, affects the strength of nucleic acid binding. Electronic effects from cationic substituents as well as hydrogen bonding from the imidazole nitrogens also contribute to the nucleic acid affinity. The bis(amidinoindoles) show no structurally associated differential in nucleic acid base pair specificity or affinity.
Fairley,Tidwell,Donkor,Naiman,Ohemeng,Lombardy,Bentley,Cory
p. 1746 - 1753
(2007/10/02)

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Chemical Properties

Boiling Point: 363.395 °C at 760 mmHg
Flash Point:173.575 °C
Density: 1.448 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.696
PKA: 13.70±0.50(Predicted)
PSA: 101.91000
LogP: 2.09750

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