- Black disperse dye composition having high color fastness to washing without the effects of metamerism
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The present invention provides a black disperse dye composition which comprises a blue disperse dye represented by chemical formula 1 or chemical formula 2, a yellow disperse dye, and a red disperse dye, and which has high fastness to washing without meta
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Paragraph 0053
(2020/10/10)
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- NOVEL PROCEDURE FOR THE FORMATION OF 2H-BENZOTRIAZOLE BODIES AND CONGENERS
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The present invention relates to a process for the preparation of 2H-benzotriazole compounds and congeners, novel 2H-benzotriazole compounds and congeners and their use as UV absorbers in coatings and bulk plastics.
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Page/Page column 35
(2020/07/05)
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- Method of constructing alpha-glucosidase inhibitor in three steps by taking imine as initial raw material
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The invention relates to a method of constructing an alpha-glucosidase inhibitor in three steps by taking imine as an initial raw material. By taking (E)-N-butyl-1-(4-nitryl phenyl) methylenimine as areaction raw material, the alpha-glucosidase inhibitor is synthesized successfully through three reaction steps: carbonylation reaction, reduction reaction and sulfonation reaction. The method has the characteristics of being novel in synthetic means, simple to operate, excellent in yield and the like.
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Paragraph 0023-0050
(2019/03/08)
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- Carbonylation Access to Phthalimides Using Self-Sufficient Directing Group and Nucleophile
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Herein we report a novel palladium-catalyzed oxidative carbonylation reaction for the synthesis of phthalimides with high atom- and step-economy. In our strategy, the imine and H2O, which are generated in situ from the condensation of aldehyde and amine, serve as self-sufficient directing group and nucleophile, respectively. This method provides rapid access to phthalimides starting from readily available materials in a one-pot manner. Various phthalimide derivatives are constructed efficiently, including medicinally and biologically active phthalimide-containing compounds.
- Ji, Fanghua,Li, Jianxiao,Li, Xianwei,Guo, Wei,Wu, Wanqing,Jiang, Huanfeng
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p. 104 - 112
(2018/02/19)
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- Method for one-pot synthesis of alpha-glucosidase inhibitor by carbonylation reaction
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The invention relates to a method for one-pot synthesis of an alpha-glucosidase inhibitor by carbonylation reaction. The method employs 4-nitrobenzaldehyde and n-butylamine as the reaction raw materials to carry out amine-aldehyde condensation, oxidative carbonylation reaction, nitro group reduction and sulfonation reaction so as to successfully synthesize the alpha-glucosidase inhibitor. The method has novel synthesis means, successfully synthesizes the alpha-glucosidase inhibitor by carbonylation reaction, and has the advantages of simple and easily available reaction raw materials, mild reaction conditions, and good atom economy and step economy of reaction, thus according with the development requirements of green chemistry.
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Paragraph 0030; 0031; 0032
(2017/10/10)
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- Chemoselective Deprotection of Sulfonamides under Acidic Conditions: Scope, Sulfonyl Group Migration, and Synthetic Applications
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Chemoselective acidic hydrolysis of sulfonamides with trifluoromethanesulfonic acid has been evaluated as a deprotection method and further extended to more complex synthetic applications. In contrast to conventional troublesome sulfonamide hydrolysis, a near-stoichiometric amount of acid was found to be sufficient to bring about efficient deprotection of various neutral or electron-deficient N-arylsulfonamides, whereas electron-rich substrates provided sulfonyl group migration products. The deprotection method developed is fully selective for N-arylsulfonamides, and the possibility to discriminate among various different sulfonamides is demonstrated.
- Javorskis, Tomas,Orentas, Edvinas
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p. 13423 - 13439
(2017/12/26)
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- New insight into probe-location dependent polarity and hydration at lipid/water interfaces: Comparison between gel- and fluid-phases of lipid bilayers
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Environment polarity and hydration at lipid/water interfaces play important roles in membrane biology, which are investigated here using a new homologous series of 4-aminophthalimide-based fluorescent molecules (4AP-Cn; n = 2-10, 12) having different lipophilicities (octanol/water partition coefficient-log-P). We show that 4AP-Cn molecules probe a peculiar stepwise polarity (ENT) profile at the lipid/water interface of the gel-phase (Lβ′) DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) bilayer at room temperature, which was not anticipated in earlier studies. However, the same molecules probe only a subtle but continuous polarity change at the interface of water and the fluid-phase (Lα) DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) bilayer at room temperature. Fluorescence quenching experiments indicate that solutes with different log-P values adsorb at different depths across DPPC/water and DOPC/water interfaces, which correlate with the polarity profiles observed at the interfaces. Molecular dynamics simulations performed on eight probe-lipid systems (four in each of the DPPC and DOPC bilayers-a total run of 2.6 μs) support experimental results, providing further information on the relative position and angle distributions as well as hydration of probes at the interfaces. Simulation results indicate that besides positions, probe orientations also play an important role in defining the local dielectric environment by controlling the probes' exposure to water at the interfaces especially of the gel-phase DPPC bilayer. The results suggest that 4AP-Cn probes are well suited for studying solvation properties at lipid/water interfaces of gel- and fluid-phases simultaneously.
- Singh, Moirangthem Kiran,Shweta, Him,Khan, Mohammad Firoz,Sen, Sobhan
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p. 24185 - 24197
(2016/09/12)
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- Azo-functionalized dendrimers
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We report the synthesis of azo-functionalized Starburst polyamidoamine (PAMAM) dendrimers. The following three systems of azo-functionalized PAMAM dendrimers were prepared by different synthetic routes: (i) phenylazo derivatives; (ii) naphthalimide azo derivatives; and (iii) phthalimide azo derivatives. Model compounds in each system were synthesized for spectroscopic comparison. Confirmation of structure was achieved using a combination of NMR and IR spectroscopy to ascertain the functional sites (i.e., the azo and the cyclic imides), while mass spectrometry and UV-vis spectrophotometry were employed to ascertain the extent of functionalization. Substitution by the azo pendent groups increased the thermal stability of PAMAM dendrimers (TGA weight loss of the naphthalimide azo-functionalized PAMAM dendrimers up to 300°C, ca. 5%).
- Cheon, Kap-Soo,Kazmaier, Peter M.,Keum, Sam-Rok,Park, Kuk-Tae,Buncel, Erwin
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p. 551 - 566
(2007/10/03)
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- Glucagon antagonists/inverse agonists
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Disclosed is a novel class of compounds of formula (I) wherein V, A, Y, Z, R1, E, X and D are as defined in the specification. These compounds act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor, the compounds are suitable for treating or preventing glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
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- Hydrophobicity-induced aggregation of N-alkyl-4-aminophthalimides in aqueous media probed by solvatochromic fluorescence
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The fluorescence response of a series of n-alkanes of different chain length, all labelled with an environmentally sensitive fluorophore, is reported in aqueous media. It is shown that solvent-sensitive fluorescence properties of 4-aminophthalimide allow one to monitor subtle changes in the microenvironment of the fluorophore resulting from aggregation or self-coiling of the molecules. A new fluorescence that is observed in aqueous media for the higher homologues of the series has been unambiguously assigned to the aggregates of the molecules.
- Saroja,Samanta
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p. 3141 - 3145
(2007/10/03)
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