- CROSSLINKED POLY-DEPSIPEPTIDE COPOLYMERS AND METHODS OF MAKING THEREOF
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Aspects of the present disclosure include methods for preparing crosslinked polydepsipeptide copolymers by stereolithography (e.g., 3-D printing). In practicing methods according to certain embodiments, a crosslinkable copolymer containing a depsipeptide
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Paragraph 0257; 0259
(2016/04/19)
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- Three-dimensional fabrication of cell-laden biodegradable poly(ethylene glycol-co-depsipeptide) hydrogels by visible light stereolithography
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Stereolithography (SLA) holds great promise in the fabrication of cell-laden hydrogels with biomimetic complexity for use in tissue engineering and pharmaceutics. However, the availability of biodegradable photocrosslinkable hydrogel polymers for SLA is v
- Elomaa, Laura,Pan, Chi-Chun,Shanjani, Yaser,Malkovskiy, Andrey,Sepp?l?, Jukka V.,Yang, Yunzhi
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p. 8348 - 8358
(2015/11/09)
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- Biodegradable photocrosslinkable poly(depsipeptide-co-caprolactone) for tissue engineering: Synthesis, characterization, and in vitro evaluation
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Stereolithography has become increasingly popular in scaffold fabrication due to automation and well-controlled geometry complexity, and consequently, there is a great need for new suitable biodegradable photocrosslinkable polymers. In this study, a new type of photocrosslinkable poly(ester amide) was synthesized based on e-caprolactone and L-alaninederived depsipeptide and was applied to fabrication of threedimensional (3D) scaffolds by stereolithography. 1H nuclear magnetic resonance and Fourier transform infra-red analysis confirmed the formation of new bonds during the polymer synthesis. Incorporation of depsipeptide increased the glass transition temperature and hydrophilicity of the polymer and accelerated hydrolytic degradation compared with the poly(ecaprolactone) homopolymer. The compressive strength of the 3D scaffolds increased with the increasing depsipeptide content. This work demonstrated that incorporation of depsipeptide into photocrosslinkable polyesters resulted in excellent cytocompatibility and tunable degradation rates and mechanical properties and thus expanded the repertoire of biomaterials suitable for 3D photofabrication of high-resolution tissue engineering scaffolds.
- Elomaa, Laura,Kang, Yunqing,Sepp?l?, Jukka V.,Yang, Yunzhi
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p. 3307 - 3315
(2015/02/19)
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- One-pot synthesis of phenylseleno N-acetyl α-amino acids: Supra-molecular self-assembling in organoselenium compounds
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A convenient one-pot synthesis of phenylseleno N-acetyl α-amino acids, PhSeCH2C(O)NHC(R)COOH (R = H (1), Me (2), PhCH2 (3), 4-HOC6H4CH2 (4) and CH2OH (5)) is reported. These compounds have been characterized by microanalyses, UV-Vis, IR and NMR (1H, 13C, 77Se) spectroscopy. The molecular structures of [PhSeCH2CONHCH2COOH] (1), [PhSeCH2CONHCH(CH2C6H4OH-4)COOH] (4) and [PhSeCH2CONHCH(CH2OH)COOH] (5) have been established by X-ray diffraction analyses. These compounds are associated in the solid state through hydrogen bonding to give supra-molecular self-assembled structures. Free radical scavenging activity of these compounds has also been evaluated by DPPH assay.
- Parashiva Prabhu,Phadnis, Prasad P.,Wadawale, Amey,Priyadarsini, K. Indira,Jain, Vimal K.
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p. 140 - 147
(2013/10/01)
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- Efficient synthesis of 2,5-diketopiperazines by Staudinger-mediated cyclization
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Solution- and solid-phase Staudinger-mediated cyclizations were assessed to efficiently prepare hetero-2,5-diketopiperazines from their protected azido dipeptide thioesters under microwave irradiation. Short reaction time, good yields and ease of purification are the main assets of this methodology. Georg Thieme Verlag Stuttgart · New York.
- Beagle, Lucas K.,Hansen, Finn K.,Monbaliu, Jean-Christophe M.,Desrosiers, Michael P.,Phillips, Angela M.,Stevens, Christian V.,Katritzky, Alan R.
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supporting information
p. 2337 - 2340
(2013/07/11)
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- Synthesis and transport studies of model dipeptides with modified N-terminal amino groups into E. coli K12 mutant strains
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The synthesis of Interminable guanidine derivatives of three dipeptides Ala-Ala, Ala-Leu, Ala-Phe and three dipeptides containing betaine as an N-terminal amino acid: Bet-Ala, Bet-Leu, Bet-He has been carried out. The transport studies of the obtained pseudopeptides and corresponding natural peptides into E. coli Kl2 mutant strains have also been performed. The results indicate that modified dipeptides containing N-terminal guanidine or betaine are not transported into E. coli K12 cells.
- Nowak-Jary,Andruszkiewicz
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experimental part
p. 1959 - 1966
(2010/07/04)
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- Reactions of N-(2-chloroacetyl)-α-amino acids with 3-cyanopyridine-2(1H)-thiones. New promising route to 3,4- dihydropyrido[3′,2′:4,5]thieno[3,2-e][1,4]diazepine-2(1H),5-diones
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The reactions of N-(2-chloroacetyl)-α-amino acids with 3-cyanopyridine-2(1H)-thiones afforded N-(3-ammothieno[2,3-b]pyridin-2- ylcarbonyl)-α-amino acids. Heating of the latter smoothly produced 3,4-dihydropyrido[3′,2′:4,5]thieno[3,2-e][1,4]diazepine-2(1H), 5-diones in high yields.
- Fedorov,Shestopalov,Belyakov
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p. 2197 - 2202
(2007/10/03)
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- Bioabsorbable polydepsipeptides, their preparation and use
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Novel, semi-crystalline depsipeptide polymers and copolymers particularly suitable for use in fabricating bioabsorbable medical implant devices such as sutures or clips and obtained through ring-opening polymerization of certain 3-substituted-2,5-morpholi
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