- Pillar[5]arene-Based Polycationic Glyco[2]rotaxanes Designed as Pseudomonas aeruginosa Antibiofilm Agents
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Pseudomonas aeruginosa (P.A.) is a human pathogen belonging to the top priorities for the discovery of new therapeutic solutions. Its propensity to generate biofilms strongly complicates the treatments required to cure P.A. infections. Herein, we describe the synthesis of a series of novel rotaxanes composed of a central galactosylated pillar[5]arene, a tetrafucosylated dendron, and a tetraguanidinium subunit. Besides the high affinity of the final glycorotaxanes for the two P.A. lectins LecA and LecB, potent inhibition levels of biofilm growth were evidenced, showing that their three subunits work synergistically. An antibiofilm assay using a double δlecAδlecB mutant compared to the wild type demonstrated that the antibiofilm activity of the best glycorotaxane is lectin-mediated. Such antibiofilm potency had rarely been reached in the literature. Importantly, none of the final rotaxanes was bactericidal, showing that their antibiofilm activity does not depend on bacteria killing, which is a rare feature for antibiofilm agents.
- Coenye, Tom,De Winter, Julien,Diaconu, Andrei,Fransolet, Maude,Gillon, Emilie,Imberty, Anne,Jimmidi, Ravikumar,Michiels, Carine,Mohy El Dine, Tharwat,Vincent, Stéphane P.
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supporting information
p. 14728 - 14744
(2021/10/12)
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- Substituted Propargylamines—Acid Corrosion Inhibitors for Steel in Petroleum Industry
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Secondary and tertiary amines of the acetylene series of various structures (14 compounds) were synthesized based on propargylamine. The possibility of a significant inhibition with these substances of low-carbon steel corrosion in hot solutions of hydrochloric acid was established. The protective effect of acetylenic amines rose with an increase in their content in an aggressive environment and with an increase in its temperature. The maximum protection effect is provided by tertiary amines containing 2,3-epoxypropyl or 2,3-epithiopropyl as a substituent. The presence of chemically active epoxy and epithio groups in the structure of these acetylenic compounds promoted the stimulation of their polymerization on the steel surface through the opening of C≡C bonds, leading to the rapid formation of a protective polymer film on it.
- Avdeev, Ya. G.,Dzhafarova, U. Sh.,Shatirova, M. I.
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p. 1088 - 1096
(2021/11/30)
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