- 1,3-DIARYL-2,2-DIHALOAZIRIDINES IN NITRATION AND BROMINATION REACTIONS
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In the nitration of 3-(4-nitrophenyl)-1-phenyl-2,2-dichloroaziridine in acetic acid, 1-(o- and p-nitrophenyl)-derivatives are formed in a 35:65 ratio. 1,3-Diphenyl-2,2-dichloroaziridine undergoes opening of the three-membered ring under the same conditions, forming a mixture of o- and p-nitroanilides and 2-nitro-4-chloroanilides of 2-acetoxy (or 2-chloro)-2-phenylacetic acids.The bromination of 3-(4-nitrophenyl)-1-phenyl-2,2-dichloroaziridine in aqueous acetic acid leads to 1-(4-bromophenyl)-3-(4-nitrophenyl)-2,2-dichloroaziridine, while in a mixture of acetic acid and acetic anhydride it leads to the anilide of 2-bromo-2-phenylacetic acid and 2-bromo-N-(2,4-dibromophenyl)-1-(4-nitrophenyl)-2,2-dichloroethylamine.
- Khlebnikov, A. F.,Kostikov, R. R.
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p. 739 - 744
(2007/10/02)
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- 7-Amino and 7-alkanoylamino 2-oxo-3-phenylindolines
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7-Amino and 7-alkanoylamino-2-oxo-3-phenylindolines, useful as anti-inflammatory and anti-thrombotic agents.
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